State Key Laboratory of Pulp and Paper Engineering, South China University of Technology, Guangzhou, 510640, China.
Materials Science Institute of Madrid, CSIC, Calle Sor Juana Inés de la Cruz 3, Madrid, 28049, Spain.
Adv Healthc Mater. 2022 Jun;11(12):e2102367. doi: 10.1002/adhm.202102367. Epub 2022 Mar 20.
This study shows the effective use of MXene-based nanomaterials to improve the performance of biocomposite sponges in wound healing. In this way, diverse chitin/MXene composite sponges are fabricated by incorporating MXene-based nanomaterials with various morphology (accordion-shaped, intercalated, single-layer, gold nanoparticles (AuNPs)-loaded single-layer) into the network of chitin sponge (CH), which can prevent massive blood losses and promote the healing process of bacterial-infected wounds. With the addition of MXene-based nanomaterials, the hemostatic efficacy of CH is enhanced due to the improved hemophilicity and accelerated blood coagulation kinetics. Furthermore, the composite sponges show a predominant antibacterial activity through the synergy between the capture and the photothermal effects. Importantly, the addition of AuNPs to composite sponges further improves hemostatic performance and promotes normal skin cell migration to heal the infected wound, achieving wound closure rates of 84% on day 9. These initial studies expand the applications of MXene-based nanomaterials in biomedical fields.
这项研究展示了 MXene 基纳米材料在改善用于伤口愈合的生物复合海绵性能方面的有效应用。通过将具有不同形态（手风琴状、层间、单层、负载金纳米粒子（AuNPs）的单层）的 MXene 基纳米材料纳入甲壳素海绵（CH）的网络中，制备了多种甲壳素/MXene 复合海绵，这可以防止大量失血并促进细菌感染伤口的愈合过程。由于提高了亲血性和加速了血液凝固动力学，添加 MXene 基纳米材料可增强 CH 的止血功效。此外，通过捕获和光热效应的协同作用，复合海绵表现出优异的抗菌活性。重要的是，在复合海绵中添加 AuNPs 可进一步提高止血性能并促进正常皮肤细胞迁移以治愈感染伤口，在第 9 天实现了 84%的伤口闭合率。这些初步研究扩展了 MXene 基纳米材料在生物医学领域的应用。
