Nagao S, Momma F, Nishiura T, Murota T, Suga M
Exp Neurol. 1986 Jun;92(3):553-62. doi: 10.1016/0014-4886(86)90297-9.
The correlation of changes in cortical neuron activity with water content and local cerebral blood flow was investigated in cats with brain edema produced by air exposure. The further effect of high-dose methylprednisolone on these factors was studied. Six hours after exposure of the brain surface to air, the water content of the white matter significantly increased. The local blood flow of the cortex and white matter significantly decreased with significant suppression of cortical neural activity (direct cortical response), indicating that ischemia was responsible for neural suppression. A single, large dose of methylprednisolone (30 mg/kg, i.v.) at the beginning of air exposure significantly reduced brain edema of the cortex and white matter 12 h after air exposure and improved the local blood flow of the cortex. Methylprednisolone also caused a remarkable improvement in cortical neural activity. This steroid effect on cortical neural function may play a role in the rapid neurologic improvement observed with their use in addition to the effect on brain edema.
在通过暴露于空气产生脑水肿的猫中，研究了皮质神经元活动变化与含水量和局部脑血流量之间的相关性。还研究了高剂量甲基强的松龙对这些因素的进一步影响。脑表面暴露于空气6小时后，白质含水量显著增加。皮质和白质的局部血流量显著降低，同时皮质神经活动（直接皮质反应）受到显著抑制，表明缺血是神经抑制的原因。在暴露于空气开始时单次静脉注射大剂量甲基强的松龙（30mg/kg）可显著减轻暴露于空气12小时后皮质和白质的脑水肿，并改善皮质的局部血流量。甲基强的松龙还显著改善了皮质神经活动。这种类固醇对皮质神经功能的作用可能除了对脑水肿的影响外，还在使用它们时观察到的快速神经功能改善中发挥作用。
