Shouse M N
Exp Neurol. 1986 Jun;92(3):601-8. doi: 10.1016/0014-4886(86)90302-x.
This study replicated and extended previous work indicating a reciprocal relationship between persistent sleep disorders and seizure susceptibility in amygdala-kindled cats. Eight kindled cats (experimental group) and six nonkindled cats (control group) were assessed for several sleep and waking state parameters. Seizure susceptibility, indexed by thresholds to generalized afterdischarge and tonic-clonic convulsions, was also evaluated in experimental subjects during each of the following states: alert but quiet wakefulness, slow-wave sleep, transitions from slow-wave to REM sleep, and REM sleep. There were two primary findings: (i) slow-wave sleep and transitions from it to REM sleep were disrupted in amygdala-kindled cats whereas REM sleep was normal when an effective transition had been made; and (ii) disturbed states were also more susceptible to generalized seizures than were stable REM sleep and waking episodes, suggesting that abnormal rather than normal sleep created a predisposition for seizures.
本研究重复并扩展了先前的工作，这些工作表明在杏仁核点燃的猫中，持续性睡眠障碍与癫痫易感性之间存在相互关系。对八只点燃猫（实验组）和六只未点燃猫（对照组）的几个睡眠和觉醒状态参数进行了评估。还在实验对象处于以下每种状态时评估了癫痫易感性，以全身性放电后阈值和强直阵挛性惊厥为指标：警觉但安静的觉醒、慢波睡眠、从慢波睡眠到快速眼动睡眠的转换以及快速眼动睡眠。有两个主要发现：（i）杏仁核点燃的猫中慢波睡眠以及从慢波睡眠到快速眼动睡眠的转换受到干扰，而当实现有效转换时快速眼动睡眠是正常的；（ii）与稳定的快速眼动睡眠和觉醒发作相比，受干扰状态也更容易发生全身性癫痫发作，这表明异常而非正常睡眠会引发癫痫易感性。
