• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

硫普罗宁对苯并(a)芘遗传毒性作用的保护效果。

The protective effect of Thiola against the genotoxic action of benzo(a)pyrene.

作者信息

Galdean D, Petrasincu D, Alangiu P, Ibric S, Voiculetz N

出版信息

Experientia. 1986 May 15;42(5):572-4. doi: 10.1007/BF01946709.

DOI:10.1007/BF01946709
PMID:3709766
Abstract

The protective effect of Thiola against the genotoxicity, induced by benzo(a)pyrene, in vitro and in vivo, was investigated. By association of Thiola to benzo(a)pyrene a significant decrease of the numerical and structural chromosome aberrations and a reduction of the incidence of c-mitoses has been obtained in human diploid cells, i.e. human embryonic lung fibroblasts of the cell-line ICP-23, and C56B1/6 mouse bone marrow cells.

摘要

研究了硫普罗宁对苯并(a)芘在体外和体内诱导的遗传毒性的保护作用。将硫普罗宁与苯并(a)芘联合使用后，在人二倍体细胞（即细胞系ICP-23的人胚胎肺成纤维细胞）和C56B1/6小鼠骨髓细胞中，染色体数目和结构畸变显著减少，c-有丝分裂发生率降低。

相似文献

1
The protective effect of Thiola against the genotoxic action of benzo(a)pyrene.硫普罗宁对苯并(a)芘遗传毒性作用的保护效果。
Experientia. 1986 May 15;42(5):572-4. doi: 10.1007/BF01946709.
2
Protection of mouse chromosomes against whole-body gamma irradiation by SH-compounds.巯基化合物对小鼠染色体免受全身γ射线照射的保护作用。
Br J Radiol. 1986 Jun;59(702):625-7. doi: 10.1259/0007-1285-59-702-625.
3
Radiation protection of bone marrow lymphocytes by 2-mercaptopropionylglycine (MPG).2-巯基丙酰甘氨酸（MPG）对骨髓淋巴细胞的辐射防护作用
Experientia. 1978 Dec 15;34(12):1627-8. doi: 10.1007/BF02034716.
4
The protective role of thiola and soybean seeds against the genotoxicity induced by potassium dichromate in mice.
Mutat Res. 2002 May 27;517(1-2):1-12. doi: 10.1016/s1383-5718(02)00013-x.
5
Evaluation of genotoxic and cytotoxic potential of thiola (N-2-mercaptopropionylglycine), a medicine used in the treatment of humans contaminated with mercury.硫普罗宁（N-2-巯基丙酰甘氨酸）的遗传毒性和细胞毒性评估，硫普罗宁是一种用于治疗汞污染人群的药物。
Environ Mol Mutagen. 2002;39(1):18-21. doi: 10.1002/em.10035.
6
Modification of benzo(a)pyrene induced chromosomal damage in mouse bone marrow by vitamin A.维生素A对苯并(a)芘诱导的小鼠骨髓染色体损伤的修饰作用。
Bull Environ Contam Toxicol. 1990 Dec;45(6):829-32. doi: 10.1007/BF01701079.
7
The anti-initiator action of p-methoxyphenol phosphate upon the transformation of normal human embryo cells induced by benzo(a)pyrene.对甲氧基苯酚磷酸酯对苯并(a)芘诱导的正常人胚胎细胞转化的抗启动作用。
Roum Arch Microbiol Immunol. 1992 Jan-Jun;51(1-2):67-74.
8
Protection of mouse thymus against cobalt-60 radiation by 2-mercaptopropionylglycine (MPG).2-巯基丙酰甘氨酸（MPG）对小鼠胸腺的钴-60辐射防护作用。
J Radiat Res. 1977 Aug;18(3):211-24. doi: 10.1269/jrr.18.211.
9
Radiation protection of mouse liver by 2-mercaptopropionylglycine.2-巯基丙酰甘氨酸对小鼠肝脏的辐射防护作用
J Radiat Res. 1977 Aug;18(3):206-10. doi: 10.1269/jrr.18.206.
10
Nickel potentiates the genotoxic effect of benzo[a]pyrene in Chinese hamster lung V79 cells.镍增强苯并[a]芘对中国仓鼠肺V79细胞的遗传毒性作用。
Environ Mol Mutagen. 2006 Apr;47(3):150-61. doi: 10.1002/em.20179.

本文引用的文献

1
Protective role of the glutathione redox cycle against adriamycin-mediated toxicity in isolated hepatocytes.谷胱甘肽氧化还原循环对阿霉素介导的离体肝细胞毒性的保护作用。
Biochem Pharmacol. 1981 Aug 15;30(16):2299-304. doi: 10.1016/0006-2952(81)90102-7.
2
Modification of the teratogenicity and mutagenicity of cyclophosphamide with thiol compounds.用硫醇化合物改变环磷酰胺的致畸性和致突变性。
Teratology. 1981 Jun;23(3):373-81. doi: 10.1002/tera.1420230312.
3
Benzo[alpha]pyrene metabolism, activation and carcinogenesis: role and regulation of mixed-function oxidases and related enzymes.
苯并[a]芘的代谢、活化与致癌作用：混合功能氧化酶及相关酶的作用与调控
Physiol Rev. 1980 Oct;60(4):1107-66. doi: 10.1152/physrev.1980.60.4.1107.
4
Mechanism of the protective action of thiol compounds in ethanol-induced liver injury.
Biochem Pharmacol. 1983 Jan 15;32(2):321-5. doi: 10.1016/0006-2952(83)90562-2.
5
Benzo[a]pyrene diol epoxide DNA adduct formation in transformable and non-transformable human foreskin fibroblast cells in vitro.
Carcinogenesis. 1982;3(7):727-32. doi: 10.1093/carcin/3.7.727.
6
Spindle disturbances in mammalian cells. II. Induction of viable aneuploid/polyploid cells and multiple chromatid exchanges after treatment of V79 Chinese hamster cells with carbaryl. Modifying effects of glutathione and S9.
Mutat Res. 1983 Mar;119(3):319-30. doi: 10.1016/0165-7992(83)90180-x.
7
Chromosome structure and function in man. I. Pachytene mapping in the male, improved methods and general discussion of initial results.人类染色体的结构与功能。I. 男性粗线期图谱，改进方法及初步结果的综合讨论。
Cytogenetics. 1971;10(1):23-32.
8
A study of the cytogenetics of the human cell strain WI-38.对人类细胞株WI-38的细胞遗传学研究。
In Vitro. 1973 Mar-Apr;8(5):353-61. doi: 10.1007/BF02619060.
9
Enzymatic conjugation of benzo (a) pyrene oxides, phenols and dihydrodiols with UDP-glucuronic acid.
Biochem Pharmacol. 1976 May 15;25(10):1221-6. doi: 10.1016/0006-2952(76)90373-7.
10
Methodological model of handling a newly isolated human diploid cell strain and its surveillance.新分离的人二倍体细胞株的处理方法模型及其监测
Arch Roum Pathol Exp Microbiol. 1977 Jan-Mar;36(1):49-54.