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美国 COVID-19 疫苗接种的影响：避免了 SARS-COV-2 相关病例、住院和死亡的负担。

The impact of COVID-19 vaccination in the US: Averted burden of SARS-COV-2-related cases, hospitalizations and deaths.

机构信息

Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, NY, United States of America.

Health Economics and Outcomes Research, New York, NY, United States of America.

出版信息

PLoS One. 2023 Apr 25;18(4):e0275699. doi: 10.1371/journal.pone.0275699. eCollection 2023.

DOI:10.1371/journal.pone.0275699
PMID:37098043
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10129007/
Abstract

By August 1, 2022, the SARS-CoV-2 virus had caused over 90 million cases of COVID-19 and one million deaths in the United States. Since December 2020, SARS-CoV-2 vaccines have been a key component of US pandemic response; however, the impacts of vaccination are not easily quantified. Here, we use a dynamic county-scale metapopulation model to estimate the number of cases, hospitalizations, and deaths averted due to vaccination during the first six months of vaccine availability. We estimate that COVID-19 vaccination was associated with over 8 million fewer confirmed cases, over 120 thousand fewer deaths, and 700 thousand fewer hospitalizations during the first six months of the campaign.

摘要

截至 2022 年 8 月 1 日，SARS-CoV-2 病毒已导致美国超过 9000 万例 COVID-19 病例和 100 万人死亡。自 2020 年 12 月以来，SARS-CoV-2 疫苗一直是美国大流行应对措施的关键组成部分；然而，疫苗的效果却不容易量化。在这里，我们使用一个动态的县级元种群模型来估计在疫苗供应的头六个月中因接种疫苗而避免的病例、住院和死亡人数。我们估计，在疫苗接种运动的头六个月中，COVID-19 疫苗接种使确诊病例减少了 800 多万例，死亡人数减少了 12 万多例，住院人数减少了 70 万例。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a294/10129007/4dc3da816ac1/pone.0275699.g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a294/10129007/96b184a82255/pone.0275699.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a294/10129007/a26798e9388d/pone.0275699.g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a294/10129007/85074077a497/pone.0275699.g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a294/10129007/4dc3da816ac1/pone.0275699.g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a294/10129007/96b184a82255/pone.0275699.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a294/10129007/a26798e9388d/pone.0275699.g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a294/10129007/85074077a497/pone.0275699.g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a294/10129007/4dc3da816ac1/pone.0275699.g004.jpg

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The impact of COVID-19 vaccination in the US: Averted burden of SARS-COV-2-related cases, hospitalizations and deaths.

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[3]
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[4]
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[5]
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[6]
Estimating COVID-19 associated hospitalizations, ICU admissions, and in-hospital deaths averted in the United States by 2023-2024 COVID-19 vaccination: A conditional probability, causal inference, and multiplier-based approach.

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[7]
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[8]
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[9]
Virologic Response and Safety of Ibuzatrelvir, A Novel SARS-CoV-2 Antiviral, in Adults With COVID-19.

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[10]
The short-term and long-term prognosis of discharged COVID-19 patients in Guangdong during the first wave of pandemic.

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本文引用的文献

[1]
Evaluation of individual and ensemble probabilistic forecasts of COVID-19 mortality in the United States.

Proc Natl Acad Sci U S A. 2022-4-12

[2]
Estimating COVID-19 Infections, Hospitalizations, and Deaths Following the US Vaccination Campaigns During the Pandemic.

JAMA Netw Open. 2022-1-4

[3]
Pfizer-BioNTech vaccine effectiveness against Sars-Cov-2 infection: Findings from a large observational study in Israel.

Prev Med. 2022-2

[4]
Lives saved and hospitalizations averted by COVID-19 vaccination in New York City: a modeling study.

Lancet Reg Health Am. 2022-1

[5]
Infections, hospitalisations, and deaths averted via a nationwide vaccination campaign using the Pfizer-BioNTech BNT162b2 mRNA COVID-19 vaccine in Israel: a retrospective surveillance study.

Lancet Infect Dis. 2022-3

[6]
Burden and characteristics of COVID-19 in the United States during 2020.

Nature. 2021-10

[7]
Vaccine effectiveness of the first dose of ChAdOx1 nCoV-19 and BNT162b2 against SARS-CoV-2 infection in residents of long-term care facilities in England (VIVALDI): a prospective cohort study.

Lancet Infect Dis. 2021-11

[8]
Safety and Efficacy of Single-Dose Ad26.COV2.S Vaccine against Covid-19.

N Engl J Med. 2021-6-10

[9]
Interim Estimates of Vaccine Effectiveness of BNT162b2 and mRNA-1273 COVID-19 Vaccines in Preventing SARS-CoV-2 Infection Among Health Care Personnel, First Responders, and Other Essential and Frontline Workers - Eight U.S. Locations, December 2020-March 2021.

MMWR Morb Mortal Wkly Rep. 2021-4-2

[10]
Health outcomes and economic burden of hospitalized COVID-19 patients in the United States.

J Med Econ. 2021

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