12-O-十四酰佛波醇-13-乙酸酯对大鼠胃体内酸分泌的抑制作用。

Inhibitory effect of 12-O-tetradecanoylphorbol 13-acetate on acid secretion by rat stomach in vivo.

作者信息

Shaw G P, Hanson P J

出版信息

FEBS Lett. 1986 Jun 9;201(2):225-8. doi: 10.1016/0014-5793(86)80613-5.

Abstract

The effect of 12-O-tetradecanoylphorbol 13-acetate (TPA) on acid secretion by rat stomach in vivo has been investigated to establish whether a previously determined inhibitory effect of TPA on aminopyrine accumulation by isolated parietal cells genuinely reflected a reduced acid secretion. Perfusion of 1 microM TPA through the lumen of the stomach had little effect on basal or carbachol-stimulated secretion, but inhibited secretion induced by histamine or pentagastrin. 4 alpha-Phorbol 12,13-didecanoate did not affect pentagastrin-stimulated secretion. It is concluded that TPA exerts a specific inhibitory effect on acid secretion in vivo, which parallels that found on aminopyrine accumulation in isolated parietal cells.

摘要

研究了12 - O - 十四烷酰佛波醇 - 13 - 乙酸酯（TPA）对大鼠胃体内酸分泌的影响，以确定TPA先前对分离壁细胞中氨基比林积累的抑制作用是否真正反映了酸分泌的减少。通过胃腔灌注1微摩尔TPA对基础或卡巴胆碱刺激的分泌几乎没有影响，但抑制组胺或五肽胃泌素诱导的分泌。4α - 佛波醇12,13 - 二癸酸酯不影响五肽胃泌素刺激的分泌。得出的结论是，TPA在体内对酸分泌具有特异性抑制作用，这与在分离壁细胞中氨基比林积累上发现的作用相似。