钙敏感磷脂依赖性蛋白激酶参与分离的大鼠壁细胞酸分泌的调控。
Involvement of calcium-sensitive phospholipid-dependent protein kinase in control of acid secretion by isolated rat parietal cells.
作者信息
Anderson N G, Hanson P J
出版信息
Biochem J. 1985 Dec 1;232(2):609-11. doi: 10.1042/bj2320609.
Abstract
The relative potency with which phorbol esters inhibited histamine-stimulated aminopyrine accumulation (an index of acid secretion) paralleled that which has been established for the activation of purified protein kinase C. The inhibitory effect of 1-oleoyl-2-acetylglycerol on aminopyrine accumulation stimulated by various secretagogues was similar to that of 12-O-tetradecanoylphorbol 13-acetate. Protein kinase C activity was present in a parietal-cell-enriched fraction. In conclusion, protein kinase C could be involved in mechanisms regulating gastric acid secretion.
摘要
佛波酯抑制组胺刺激的氨基比林蓄积（酸分泌指标）的相对效力与已确定的纯化蛋白激酶C激活的效力平行。1-油酰基-2-乙酰甘油对各种促分泌剂刺激的氨基比林蓄积的抑制作用与12-O-十四酰佛波醇-13-乙酸酯相似。蛋白激酶C活性存在于富含壁细胞的组分中。总之，蛋白激酶C可能参与调节胃酸分泌的机制。
相似文献
1
Involvement of calcium-sensitive phospholipid-dependent protein kinase in control of acid secretion by isolated rat parietal cells.
Biochem J. 1985 Dec 1;232(2):609-11. doi: 10.1042/bj2320609.
2
Sites of action of protein kinase C on secretory activity in rat parietal cells.
Am J Physiol. 1989 Jan;256(1 Pt 1):G129-38. doi: 10.1152/ajpgi.1989.256.1.G129.
3
Interaction of signal transduction pathways in mediating acid secretion by rat parietal cells.
Am J Physiol. 1989 Apr;256(4 Pt 1):C873-9. doi: 10.1152/ajpcell.1989.256.4.C873.
4
Inhibition by Ro 31-8220 of acid secretory activity induced by carbachol indicates a stimulatory role for protein kinase C in the action of muscarinic agonists on isolated rat parietal cells.
Biochem Pharmacol. 1993 Aug 17;46(4):583-8. doi: 10.1016/0006-2952(93)90541-4.
5
Effects of phorbol ester treatment on dibutyryl cyclic adenosine-5' monophosphate- and carbachol-stimulated aminopyrine accumulation in isolated rat parietal cells.
Scand J Gastroenterol. 2000 Jul;35(7):686-93. doi: 10.1080/003655200750023336.
6
Action of epidermal growth factor on acid secretion by rat isolated parietal cells.
Biochem J. 1987 Jun 15;244(3):699-704. doi: 10.1042/bj2440699.
7
Inhibitory effect of 12-O-tetradecanoylphorbol 13-acetate on acid secretion by rat stomach in vivo.
FEBS Lett. 1986 Jun 9;201(2):225-8. doi: 10.1016/0014-5793(86)80613-5.
8
Inhibition of gastric acid secretion by epidermal growth factor. Effects on cyclic AMP and on prostaglandin production in rat isolated parietal cells.
Biochem J. 1988 Nov 1;255(3):789-94. doi: 10.1042/bj2550789.
9
Inhibition of gastric acid secretion by a phorbol ester: effect of 12-O-tetradecanoylphorbol-13-acetate on aminopyrine accumulation by rat parietal cells.
Biochem Biophys Res Commun. 1984 Jun 15;121(2):566-72. doi: 10.1016/0006-291x(84)90219-5.
10
Helicobacter pylori fatty acid cis 9,10-methyleneoctadecanoic acid increases [Ca2+]i, activates protein kinase C and stimulates acid secretion in parietal cells.
Prostaglandins Leukot Essent Fatty Acids. 1998 Aug;59(2):119-25. doi: 10.1016/s0952-3278(98)90090-4.
引用本文的文献
1
Protein kinase C-alpha attenuates cholinergically stimulated gastric acid secretion of rabbit parietal cells.
Br J Pharmacol. 2003 Jun;139(3):545-54. doi: 10.1038/sj.bjp.0705211.
2
Different actions of protein kinase C isoforms alpha and epsilon on gastric acid secretion.
Br J Pharmacol. 2002 Jul;136(6):938-46. doi: 10.1038/sj.bjp.0704790.
3
Activation of Raf-1 during experimental gastric ulcer healing is Ras-mediated and protein kinase C-independent.
Am J Pathol. 1999 Nov;155(5):1759-66. doi: 10.1016/S0002-9440(10)65491-0.
4
Protein kinase C inhibits cyclic adenosine monophosphate generation by histamine and truncated glucagon like peptide 1 in the human gastric cancer cell line HGT-1.
Gut. 1993 Jul;34(7):953-7. doi: 10.1136/gut.34.7.953.
5
Interactions between intracellular cyclic AMP and agonist-induced inositol phospholipid breakdown in isolated gastric mucosal cells of the rat.
Naunyn Schmiedebergs Arch Pharmacol. 1987 Nov;336(5):471-7. doi: 10.1007/BF00169301.
6
Inhibition of gastric acid secretion by epidermal growth factor. Effects on cyclic AMP and on prostaglandin production in rat isolated parietal cells.
Biochem J. 1988 Nov 1;255(3):789-94. doi: 10.1042/bj2550789.
7
Action of epidermal growth factor on acid secretion by rat isolated parietal cells.
Biochem J. 1987 Jun 15;244(3):699-704. doi: 10.1042/bj2440699.
8
Protein kinase C inhibits stimulation of adenylate cyclase by the histamine H2 receptor in rat parietal cells.
Agents Actions. 1992 Sep;37(1-2):25-9. doi: 10.1007/BF01987886.
本文引用的文献
1
Protein measurement with the Folin phenol reagent.
J Biol Chem. 1951 Nov;193(1):265-75.
2
Secretagogue stimulation of [14C]aminopyrine accumulation by isolated canine parietal cells.
Am J Physiol. 1980 Apr;238(4):G366-75. doi: 10.1152/ajpgi.1980.238.4.G366.
3
Direct activation of calcium-activated, phospholipid-dependent protein kinase by tumor-promoting phorbol esters.
J Biol Chem. 1982 Jul 10;257(13):7847-51.
4
Calcium-dependent protein kinase: widespread occurrence in various tissues and phyla of the animal kingdom and comparison of effects of phospholipid, calmodulin, and trifluoperazine.
Proc Natl Acad Sci U S A. 1980 Dec;77(12):7039-43. doi: 10.1073/pnas.77.12.7039.
5
Inhibition of gastric acid secretion by a phorbol ester: effect of 12-O-tetradecanoylphorbol-13-acetate on aminopyrine accumulation by rat parietal cells.
Biochem Biophys Res Commun. 1984 Jun 15;121(2):566-72. doi: 10.1016/0006-291x(84)90219-5.
6
Identification and characterization of Ca2+-phospholipid-dependent protein kinase in rat islets and hamster beta-cells.
Biochem J. 1984 Apr 15;219(2):547-51. doi: 10.1042/bj2190547.
7
Phosphatidylinositol turnover in platelet activation; calcium mobilization and protein phosphorylation.
Cell Calcium. 1982 Oct;3(4-5):323-35. doi: 10.1016/0143-4160(82)90020-3.
8
Potentiating interactions of gastric stimulants on [14 C] aminopyrine accumulation by isolated canine parietal cells.
Gastroenterology. 1982 Jul;83(1 Pt 2):216-23.
9
Inositol trisphosphate and diacylglycerol as second messengers.
Biochem J. 1984 Jun 1;220(2):345-60. doi: 10.1042/bj2200345.
10
Metabolism and gastric acid secretion. Substrate-dependency of aminopyrine accumulation in isolated rat parietal cells.
Biochem J. 1985 Apr 1;227(1):223-9. doi: 10.1042/bj2270223.
Zotero 插件