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钙敏感磷脂依赖性蛋白激酶参与分离的大鼠壁细胞酸分泌的调控。

Involvement of calcium-sensitive phospholipid-dependent protein kinase in control of acid secretion by isolated rat parietal cells.

作者信息

Anderson N G, Hanson P J

出版信息

Biochem J. 1985 Dec 1;232(2):609-11. doi: 10.1042/bj2320609.

DOI:10.1042/bj2320609
PMID:4091811
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1152923/
Abstract

The relative potency with which phorbol esters inhibited histamine-stimulated aminopyrine accumulation (an index of acid secretion) paralleled that which has been established for the activation of purified protein kinase C. The inhibitory effect of 1-oleoyl-2-acetylglycerol on aminopyrine accumulation stimulated by various secretagogues was similar to that of 12-O-tetradecanoylphorbol 13-acetate. Protein kinase C activity was present in a parietal-cell-enriched fraction. In conclusion, protein kinase C could be involved in mechanisms regulating gastric acid secretion.

摘要

佛波酯抑制组胺刺激的氨基比林蓄积（酸分泌指标）的相对效力与已确定的纯化蛋白激酶C激活的效力平行。1-油酰基-2-乙酰甘油对各种促分泌剂刺激的氨基比林蓄积的抑制作用与12-O-十四酰佛波醇-13-乙酸酯相似。蛋白激酶C活性存在于富含壁细胞的组分中。总之，蛋白激酶C可能参与调节胃酸分泌的机制。

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1
Involvement of calcium-sensitive phospholipid-dependent protein kinase in control of acid secretion by isolated rat parietal cells.钙敏感磷脂依赖性蛋白激酶参与分离的大鼠壁细胞酸分泌的调控。
Biochem J. 1985 Dec 1;232(2):609-11. doi: 10.1042/bj2320609.
2
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本文引用的文献

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Protein measurement with the Folin phenol reagent.使用福林酚试剂进行蛋白质测定。
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Secretagogue stimulation of [14C]aminopyrine accumulation by isolated canine parietal cells.促分泌素对离体犬壁细胞[14C]氨基比林蓄积的刺激作用。
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Direct activation of calcium-activated, phospholipid-dependent protein kinase by tumor-promoting phorbol esters.肿瘤促进剂佛波酯对钙激活的、磷脂依赖性蛋白激酶的直接激活作用。
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4
Calcium-dependent protein kinase: widespread occurrence in various tissues and phyla of the animal kingdom and comparison of effects of phospholipid, calmodulin, and trifluoperazine.钙依赖性蛋白激酶：在动物界的各种组织和门类中广泛存在，以及磷脂、钙调蛋白和三氟拉嗪的作用比较。
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5
Inhibition of gastric acid secretion by a phorbol ester: effect of 12-O-tetradecanoylphorbol-13-acetate on aminopyrine accumulation by rat parietal cells.佛波酯对胃酸分泌的抑制作用：12 - O - 十四烷酰佛波醇 - 13 - 乙酸酯对大鼠壁细胞氨基比林蓄积的影响
Biochem Biophys Res Commun. 1984 Jun 15;121(2):566-72. doi: 10.1016/0006-291x(84)90219-5.
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Identification and characterization of Ca2+-phospholipid-dependent protein kinase in rat islets and hamster beta-cells.大鼠胰岛和仓鼠β细胞中钙磷脂依赖性蛋白激酶的鉴定与特性分析
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Phosphatidylinositol turnover in platelet activation; calcium mobilization and protein phosphorylation.血小板激活中的磷脂酰肌醇周转；钙动员与蛋白质磷酸化。
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Potentiating interactions of gastric stimulants on [14 C] aminopyrine accumulation by isolated canine parietal cells.胃刺激剂对离体犬壁细胞积累[14C]氨基比林的增强相互作用。
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Inositol trisphosphate and diacylglycerol as second messengers.肌醇三磷酸和二酰甘油作为第二信使。
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10
Metabolism and gastric acid secretion. Substrate-dependency of aminopyrine accumulation in isolated rat parietal cells.代谢与胃酸分泌。大鼠离体壁细胞中氨基比林蓄积的底物依赖性。
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