与3-甲基胆蒽诱导的大鼠纤维肉瘤胞质溶胶部分相关的免疫调节活性——II. 与多胺复合物的关联
Immunomodulating activities associated with the cytosol fraction of a 3-methylcholanthrene-induced rat fibrosarcoma--II. Association with polyamine complexes.
作者信息
Pommier G J, Garrouste F, Remacle-Bonnet M M, Depieds R C
出版信息
Int J Biochem. 1986;18(6):557-64. doi: 10.1016/0020-711x(86)90168-0.
PMID:3709937
Abstract
This paper characterizes the molecular nature of the factors present in cytosol from F-344 rat McFiFi2(s) fibrosarcoma cells (FiCF) which mediate inhibition of PHA-induced lymphoproliferative responses. These are polyamines (spermine/spermidine) conjugated to different protein carriers. Interaction of these complexes with polyamine oxidase (PAO) present in fetal calf or rat serum is responsible of the suppression observed.
摘要
本文描述了F-344大鼠McFiFi2(s)纤维肉瘤细胞（FiCF）胞质溶胶中存在的介导抑制PHA诱导的淋巴细胞增殖反应的因子的分子性质。这些因子是与不同蛋白质载体结合的多胺（精胺/亚精胺）。这些复合物与胎牛血清或大鼠血清中存在的多胺氧化酶（PAO）相互作用导致了所观察到的抑制作用。
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