Michael Sayegh Faculty of Pharmacy, Aqaba University of Technology, Aqaba, Jordan.
Medical Pharmacology Department, Faculty of Medicine, Cairo University, Giza, Egypt.
Int J Immunopathol Pharmacol. 2023 Jan-Dec;37:3946320231172745. doi: 10.1177/03946320231172745.
Testicular dysfunction has been associated with chronic hyperglycemia in diabetes mellitus patients. We investigated taurine's possible mechanisms and protective effects against testicular damage using a rat model of streptozotocin-induced diabetes.
Wistar rats ( = 56) were divided into seven equal groups. Untreated control rats received saline, and treated control rats received taurine 50 mg/kg orally. To induce diabetes, rats received a single dose of streptozotocin. Metformin-treated diabetic rats received metformin at a dose of 300 mg/kg. Taurine-treated groups received 10, 25, or 50 mg/kg. All treatments were provided orally once a day for 9 weeks following the streptozotocin injection. Levels of blood glucose, serum insulin, cholesterol, testicular tumour necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), interleukin-1beta (IL-1β), malondialdehyde (MDA), superoxide dismutase (SOD), glutathione peroxidase (GPx), glutathione (GSH), and catalase (CAT) were examined. Sperm count, progressive sperm motility, and sperm abnormalities were examined. Body and relative reproductive gland weights were assessed. Histopathological examinations of the testes and epididymis were performed.
Metformin as well as taurine (in a dose-dependent manner) resulted in significant improvements in body and relative reproductive gland weights, blood glucose, serum cholesterol, and insulin levels, as well as cytokine and oxidative parameters. These findings were associated with significant improvement in sperm count, progressive sperm motility, sperm abnormalities, and histopathological lesions in the testes and epididymis.
Taurine can potentially improve hyperglycemia, hypercholesterolemia, and testicular damage associated with diabetes mellitus, possibly by controlling inflammation and oxidative stress.
睾丸功能障碍与糖尿病患者的慢性高血糖有关。我们使用链脲佐菌素诱导的糖尿病大鼠模型研究牛磺酸对睾丸损伤的可能机制和保护作用。
将 56 只 Wistar 大鼠分为 7 组。未处理的对照组大鼠给予生理盐水，处理对照组大鼠给予牛磺酸 50mg/kg 口服。为诱导糖尿病，大鼠给予链脲佐菌素单次剂量。二甲双胍治疗的糖尿病大鼠给予二甲双胍 300mg/kg。牛磺酸治疗组给予 10、25 或 50mg/kg。所有治疗均在链脲佐菌素注射后每天口服一次，持续 9 周。检查血糖、血清胰岛素、胆固醇、睾丸肿瘤坏死因子-α（TNF-α）、白细胞介素-6（IL-6）、白细胞介素-1β（IL-1β）、丙二醛（MDA）、超氧化物歧化酶（SOD）、谷胱甘肽过氧化物酶（GPx）、谷胱甘肽（GSH）和过氧化氢酶（CAT）水平。检查精子计数、精子活力和精子畸形。评估体重和相对生殖腺重量。对睾丸和附睾进行组织病理学检查。
二甲双胍和牛磺酸（呈剂量依赖性）可显著改善体重和相对生殖腺重量、血糖、血清胆固醇和胰岛素水平以及细胞因子和氧化参数。这些发现与精子计数、精子活力、精子畸形以及睾丸和附睾的组织病理学病变的显著改善有关。
牛磺酸可能通过控制炎症和氧化应激来改善与糖尿病相关的高血糖、高胆固醇血症和睾丸损伤。
