Liaoning Provincial Key Laboratory of Zoonosis, College of Animal Science and Veterinary Medicine, Shenyang Agricultural University, Shenyang, Liaoning, 110866, People's Republic of China.
Experimental Animal Center, Liaoning University of Traditional Chinese Medicine, Shenyang, Liaoning, 110847, People's Republic of China.
Adv Exp Med Biol. 2017;975 Pt 2:801-811. doi: 10.1007/978-94-024-1079-2_62.
A great deal of investigations have verified that diabetic male reproductive impairment is associated with the dysfunction of testicular steroidogenesis and spermatogenesis resulted from insulin deficiency and hyperglycaemia-induced oxidative stress. It has been identified taurine is profitable for diabetes mellitus and diabetic implications through its insulin-like and islet cells protective activity. Furthermore, our previous studies found that taurine could increase testicular antioxidative ability, stimulate the endocrine activity of hypothalamic-pituitary-testicular axis, elevate testosterone level, raise sperm quality, suppress the deterioration of testicular function. Accordingly, we hypothesized that taurine may have beneficial effects on testicular dysfunction under diabetic mellitus status. Here, we investigated the effects of taurine on testicular steroidogenesis and spermatogenesis in streptozotocin (STZ)-induced type I diabetic rats. We observed that taurine treatment can markedly increase the body and testis weights, testicular SDH and G6PDH activities, decrease the serum fasting glucose concentration of diabetic rats. Serum contents of GnRH, LH, FSH, T, and testicular StAR, 3β-HSD, 17β-HSD mRNA expression levels were also obviously raised by taurine administration, indicating that taurine can improve testicular steroidogenesis in diabetic animals. Finally, we found taurine supplementation effectively elevated the sperm count and motility, reduced sperm abnormality, suggesting that taurine can increase the testicular spermatogenesis function of diabetic rat. In summary, the present data indicated that taurine can rescue the function of testicular steroidogenesis and spermatogenesis in STZ-induced type I diabetic rats possibly by increasing the endocrine activity of hypothalamic-pituitary-testicular axis.
大量研究证实，糖尿病男性生殖功能障碍与胰岛素缺乏和高血糖诱导的氧化应激导致的睾丸类固醇生成和精子发生功能障碍有关。已经确定牛磺酸通过其胰岛素样和胰岛细胞保护活性有益于糖尿病及其并发症。此外，我们之前的研究发现，牛磺酸可以增加睾丸抗氧化能力，刺激下丘脑-垂体-睾丸轴的内分泌活动，提高睾酮水平，提高精子质量，抑制睾丸功能恶化。因此，我们假设牛磺酸可能对糖尿病状态下的睾丸功能障碍有有益的影响。在这里，我们研究了牛磺酸对链脲佐菌素（STZ）诱导的 1 型糖尿病大鼠睾丸类固醇生成和精子发生的影响。我们观察到，牛磺酸治疗可以显著增加糖尿病大鼠的体重和睾丸重量，睾丸 SDH 和 G6PDH 活性，降低血清空腹血糖浓度。牛磺酸给药还明显提高了血清 GnRH、LH、FSH、T 和睾丸 StAR、3β-HSD、17β-HSD mRNA 表达水平，表明牛磺酸可以改善糖尿病动物的睾丸类固醇生成。最后，我们发现牛磺酸补充剂有效地提高了精子计数和活力，降低了精子畸形率，表明牛磺酸可以增加糖尿病大鼠的睾丸生精功能。综上所述，本研究数据表明，牛磺酸可能通过增加下丘脑-垂体-睾丸轴的内分泌活性来挽救 STZ 诱导的 1 型糖尿病大鼠的睾丸类固醇生成和精子发生功能。
