Central Laboratory, Xiang'an Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, Fujian 361102, China; School of Life Science, Xiamen University, Xiamen, Fujian 361102, China; Fujian Health College, Fuzhou, Fujian, 350101, China.
Central Laboratory, Xiang'an Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, Fujian 361102, China; School of Medicine, Xiamen University, Xiamen, Fujian 361102, China; Fujian Health College, Fuzhou, Fujian, 350101, China.
Biomed Pharmacother. 2023 Jul;163:114764. doi: 10.1016/j.biopha.2023.114764. Epub 2023 Apr 24.
SOX2 is a transcription factor belonging to the SOX gene family, whose activity has been associated with the maintenance of the stemness and self-renewal of embryonic stem cells (ESCs), as well as the induction of differentiated cells into induced pluripotent stem cells (iPSCs). Moreover, accumulating studies have shown that SOX2 is amplified in various cancers, notably in esophageal squamous cell carcinoma (ESCC). In addition, SOX2 expression is linked to multiple malignant processes, including proliferation, migration, invasion, and drug resistance. Taken together, targeting SOX2 might shed light on novel approaches for cancer therapy. In this review, we aim to summarize the current knowledge regarding SOX2 in the development of esophagus and ESCC. We also highlight several therapeutic strategies for targeting SOX2 in different cancer types, which can provide new tools to treat cancers possessing abnormal levels of SOX2 protein.
SOX2 是一种转录因子，属于 SOX 基因家族，其活性与维持胚胎干细胞（ESCs）的干性和自我更新以及诱导分化细胞成为诱导多能干细胞（iPSCs）有关。此外，越来越多的研究表明，SOX2 在各种癌症中扩增，特别是在食管鳞状细胞癌（ESCC）中。此外，SOX2 的表达与多种恶性过程有关，包括增殖、迁移、侵袭和耐药性。综上所述，靶向 SOX2 可能为癌症治疗提供新的方法。在这篇综述中，我们旨在总结 SOX2 在食管和 ESCC 发育中的最新知识。我们还强调了几种针对不同癌症类型靶向 SOX2 的治疗策略，这可以为治疗具有异常水平 SOX2 蛋白的癌症提供新的工具。
