Zahedi Anoushiravan, Artigas Sergio Oroz, Swaboda Nora, Wiers Corinde E, Görgen Kai, Park Soyoung Q
Department of Decision Neuroscience & Nutrition, German Institute of Human Nutrition (DIfE), Nuthetal, Germany; Neuroscience Research Center, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Neuroscience Research Center, Berlin, Germany; German Center for Diabetes Research (DZD), Neuherberg, Germany; Department of Psychology, University of Muenster (Westfaelische Wilhelms-Universitaet Muenster).
Department of Psychology, University of Lübeck, Lübeck, Germany.
Neuroimage. 2023 Jul 1;274:120134. doi: 10.1016/j.neuroimage.2023.120134. Epub 2023 Apr 24.
Current theories suggest that altering choices requires value modification. To investigate this, normal-weight female participants' food choices and values were tested before and after an approach-avoidance training (AAT), while neural activity was recorded during the choice task using functional magnetic resonance imaging (fMRI). During AAT, participants consistently approached low- while avoiding high-calorie food cues. AAT facilitated low-calorie food choices, leaving food values unchanged. Instead, we observed a shift in indifference points, indicating the decreased contribution of food values in food choices. Training-induced choice shifts were associated with increased activity in the posterior cingulate cortex (PCC). In contrast, the medial PFC activity was not changed. Additionally, PCC gray matter density predicted individual differences in training-induced functional changes, suggesting anatomic predispositions to training impact. Our findings demonstrate neural mechanisms underlying choice modulation independent of valuation-related processes, which has substantial theoretical significance for decision-making frameworks and translational implications for health-related decisions resilient to value shifts.
当前理论表明，改变选择需要对价值进行调整。为了对此进行研究，在进行趋近-回避训练（AAT）前后，对正常体重女性参与者的食物选择和价值观进行了测试，同时在选择任务期间使用功能磁共振成像（fMRI）记录神经活动。在AAT期间，参与者始终趋近低热量食物线索，同时回避高热量食物线索。AAT促进了低热量食物的选择，而食物价值并未改变。相反，我们观察到无差异点的转移，这表明食物价值在食物选择中的贡献降低。训练引起的选择转移与后扣带回皮质（PCC）活动增加有关。相比之下，内侧前额叶皮质活动没有变化。此外，PCC灰质密度预测了训练引起的功能变化中的个体差异，表明存在对训练影响的解剖学易感性。我们的研究结果证明了独立于与估值相关过程的选择调节的神经机制，这对决策框架具有重要的理论意义，并且对抵抗价值转移的健康相关决策具有转化意义。
