Wecker L, Mrak R E, Dettbarn W D
Fundam Appl Toxicol. 1986 Jan;6(1):172-4. doi: 10.1016/0272-0590(86)90273-3.
Intercostal muscle samples obtained from autopsy of a 51-year-old male exposed to an organophosphate insecticide were analyzed for cholinesterase activity and muscle fiber integrity. Muscle cholinesterase activity, 5 days after exposure, was reduced to 53% of control values. Histological analysis indicated the presence of muscle fibers with subsarcolemmal grouped granular basophilic inclusions and scattered necrotic fibers. Results indicate that acute organophosphate exposure through inhalation can lead to skeletal muscle fiber damage in humans, similar to results obtained by ingestion. Furthermore, the pathology is comparable to the histological alterations observed in rats following acute injection of organophosphates.
对一名接触有机磷杀虫剂的51岁男性尸检获取的肋间肌样本进行了胆碱酯酶活性和肌纤维完整性分析。接触5天后，肌肉胆碱酯酶活性降至对照值的53%。组织学分析表明存在肌纤维，其肌膜下有成群的颗粒状嗜碱性包涵体和散在的坏死纤维。结果表明，通过吸入急性接触有机磷可导致人类骨骼肌纤维损伤，这与经口摄入所获结果相似。此外，该病理变化与大鼠急性注射有机磷后观察到的组织学改变相当。
