Wecker L, Mrak R E, Dettbarn W D
J Environ Pathol Toxicol Oncol. 1985 Nov-Dec;6(2):171-5.
Intercostal muscle samples obtained from autopsy of a 51 year old male, exposed to an organophosphate insecticide by inhalation, were analyzed for cholinesterase (ChE) activity and muscle fiber integrity. Muscle ChE activity, five days after exposure, was still reduced to 53% of control values. Histological analysis indicated the presence of muscle fibers with subsarcolemmal grouped granular basophilic inclusions and scattered necrotic fibers. Results indicate that acute organophosphate exposure through inhalation can lead to skeletal muscle fiber damage in humans, similar to results obtained by ingestion. Furthermore, the pathology is comparable to the histological alterations observed in rats following acute injection of organophosphates.
从一名51岁男性尸检中获取的肋间肌样本进行了分析，该男性因吸入有机磷杀虫剂而暴露。分析内容包括胆碱酯酶（ChE）活性和肌纤维完整性。暴露五天后，肌肉ChE活性仍降至对照值的53%。组织学分析表明存在肌纤维，其肌膜下有成群的颗粒状嗜碱性包涵体和散在的坏死纤维。结果表明，通过吸入急性接触有机磷可导致人类骨骼肌纤维损伤，这与经口摄入获得的结果相似。此外，该病理学与大鼠急性注射有机磷后观察到的组织学改变相当。
