Division of Rheumatology, Department of Internal Medicine, Istanbul University, Cerrahpaşa, Turkey.
Division of Rheumatology, New York University School of Medicine, New York, NY, USA.
Clin Immunol. 2023 Jun;251:109341. doi: 10.1016/j.clim.2023.109341. Epub 2023 Apr 24.
Disease assessment has been challenging in Behçet syndrome due to the heterogeneous disease course and multiorgan involvement with variable treatment response. There have been several recent improvements regarding outcome measures including development of a Core Set of Domains for Behçet syndrome and novel instruments for assessing specific organs and overall damage. This review focuses on the current state of outcome measures in Behçet syndrome, unmet needs, and a research agenda towards the development of standardized and validated outcome measure instruments.
由于白塞综合征的疾病过程异质性和多器官受累,且治疗反应不同,因此疾病评估一直具有挑战性。在结局测量方面,包括白塞综合征核心领域集的发展和评估特定器官和总体损害的新工具,已经有了一些近期的改进。这篇综述重点介绍了白塞综合征结局测量的现状、未满足的需求,以及制定标准化和验证结局测量工具的研究议程。