Gen Shiko, Iwai Takanori, Ohnari Sayuri, Nobe Kanako, Ikeda Naofumi
Department of Nephrology, Saitama Sekishinkai Hospital, Sayama, Japan.
Case Rep Nephrol. 2023 Apr 17;2023:4906876. doi: 10.1155/2023/4906876. eCollection 2023.
We experienced a case of myeloperoxidase antineutrophil cytoplasmic antibody (MPO-ANCA)-associated vasculitis after Moderna COVID-19 vaccination. An 82-year-old woman developed pyrexia and general malaise one month after her third booster vaccine, and the symptoms persisted. Blood testing revealed inflammation, a high level of MPO-ANCA, and microscopic hematuria. MPO-ANCA-associated vasculitis was diagnosed by renal biopsy. The symptoms improved with steroid therapy. Common adverse reactions to mRNA vaccines against COVID-19 include pyrexia and general malaise, but MPO-ANCA-associated vasculitis can also occur. If pyrexia, prolonged general malaise, urinary occult blood, or renal impairment is observed, the onset of MPO-ANCA-associated vasculitis should be considered.
我们遇到了一例在接种莫德纳新冠疫苗后发生的髓过氧化物酶抗中性粒细胞胞浆抗体（MPO-ANCA）相关血管炎病例。一名82岁女性在第三次加强疫苗接种后一个月出现发热和全身不适，症状持续存在。血液检查显示有炎症、MPO-ANCA水平升高以及镜下血尿。通过肾活检诊断为MPO-ANCA相关血管炎。经类固醇治疗后症状有所改善。针对新冠病毒的mRNA疫苗常见的不良反应包括发热和全身不适，但MPO-ANCA相关血管炎也可能发生。如果观察到发热、长期全身不适、尿潜血或肾功能损害，应考虑MPO-ANCA相关血管炎的发生。
