Aradhya Sushma, Ravishankar Namratha, Satish Suchitha
JSS Medical College and Hospital, JSS Academy of Higher Education and Research, Department of Pathology, Mysore, Karnataka, India.
Autops Case Rep. 2023 Apr 13;13:e2023428. doi: 10.4322/acr.2023.428. eCollection 2023.
Pleomorphic adenoma (PA) of the external auditory canal (EAC) is a rare clinical entity with a few cases reported in the literature. The clinical diagnosis of these lesions can be formidable due to their rarity and unusual location. This tumor occurs at various other anatomical locations apart from the major salivary glands. A 30-year-old female presented with a two-year history of a gradually enlarging and painless mass in the left external auditory canal. The tumor was excised, and histopathological and immunohistochemical evaluation revealed a mixed tumor with both epithelial and stromal components of different proportions, recognized and classified today by the World Health Organization (WHO) as a pleomorphic adenoma. The post-operative course was uneventful, and at the 10-month follow-up, no recurrence of the pleomorphic adenoma was noted. We highlight the histological features and the immunohistochemical profile of the tumor and review the literature on glandular neoplasms of the EAC and their recent classification, emphasizing on the histogenesis, clinical presentations, and microscopic features of the tumor. In addition, we aim to discuss vital features in differentiating these tumors from other tumors of the external auditory canal to enable clinicians and pathologists to recognize this uncommon benign neoplasm.
外耳道多形性腺瘤（PA）是一种临床罕见的疾病，文献报道的病例较少。由于其罕见性和不寻常的位置，这些病变的临床诊断可能具有挑战性。除主要唾液腺外，这种肿瘤还发生在其他各种解剖位置。一名30岁女性，有两年左侧外耳道逐渐增大的无痛性肿块病史。肿瘤被切除，组织病理学和免疫组织化学评估显示为一种混合瘤，具有不同比例的上皮和间质成分，如今被世界卫生组织（WHO）认定并分类为多形性腺瘤。术后过程顺利，在10个月的随访中，未发现多形性腺瘤复发。我们重点介绍了该肿瘤的组织学特征和免疫组织化学特征，并回顾了外耳道腺性肿瘤及其最新分类的文献，强调了肿瘤的组织发生、临床表现和微观特征。此外，我们旨在讨论将这些肿瘤与外耳道其他肿瘤区分开来的关键特征，以使临床医生和病理学家能够识别这种罕见的良性肿瘤。
