Zuo Yunfei, Shen Hanchen, Sun Feiyi, Li Pei, Sun Jianwei, Kwok Ryan T K, Lam Jacky W Y, Tang Ben Zhong
Department of Chemistry, Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction, and Guangdong-Hong Kong-Macau Joint Laboratory of Optoelectronic and Magnetic Functional Materials, Division of Life Science, and State Key Laboratory of Molecular Neuroscience, The Hong Kong University of Science & Technology, Clear Water Bay, Kowloon, Hong Kong 999077, P.R. China.
Department of Gastrointestinal Surgery, The Second Clinical Medical College, Shenzhen People's Hospital, Jinan University, Shenzhen, 518020, China.
ACS Bio Med Chem Au. 2022 Feb 24;2(3):236-257. doi: 10.1021/acsbiomedchemau.1c00066. eCollection 2022 Jun 15.
Cell death is closely related to various diseases, and monitoring and controlling cell death is a promising strategy to develop efficient therapy. Aggregation-induced emission luminogens (AIEgens) are ideal candidates for developing novel theranostic agents because of their intriguing properties in the aggregate state. The rational application of AIE materials in cell death-related research is still in its infancy but has shown great clinical potential. This review discussed the research frontier and our understanding of AIE materials in various subroutines of cell death, including apoptosis, necrosis, immunogenic cell death, pyroptosis, autophagy, lysosome-dependent cell death, and ferroptosis. We hope that the new insights can be offered to this growing field and attract more researchers to provide valuable contributions.
细胞死亡与多种疾病密切相关，监测和控制细胞死亡是开发有效治疗方法的一种有前景的策略。聚集诱导发光 luminogens（AIEgens）因其在聚集态下具有引人入胜的特性，是开发新型诊疗剂的理想候选物。AIE 材料在细胞死亡相关研究中的合理应用仍处于起步阶段，但已显示出巨大的临床潜力。本文综述讨论了 AIE 材料在细胞死亡的各种子程序中的研究前沿以及我们的理解，包括细胞凋亡、坏死、免疫原性细胞死亡、焦亡、自噬、溶酶体依赖性细胞死亡和铁死亡。我们希望能为这个不断发展的领域提供新的见解，并吸引更多研究人员做出有价值的贡献。
