Department of Chemistry, Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction and Guangdong-Hong Kong-Macau Joint Laboratory of Optoelectronic and Magnetic Functional Materials, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China.
Department of Laboratory Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.
ChemMedChem. 2022 Feb 4;17(3):e202100578. doi: 10.1002/cmdc.202100578. Epub 2021 Dec 4.
Efficient theranostic systems can realize better outcomes in disease treatment because of precise diagnosis and the concomitant effective therapy. Aggregation-induced emission luminogens (AIEgens) are a unique type of organic emitters with intriguing photophysical properties in the aggregate state. Among the AIEgens studied for biomedical applications, so far, metal-based AIE systems have shown great potential in theranostics due to the enhanced multimodal bioimaging ability and therapeutic effect. This research field has been growing rapidly, and many rationally designed systems with promising activities to cancer and other diseases have been reported recently. In this review, we summarized the recent progress of metal-based AIE materials in bioimaging and biological theranostics, and deciphered the pertinent design strategies. We hope that this review can offer new insights into the development of this growing field.
高效的治疗系统可以通过精确的诊断和同时进行的有效治疗来实现更好的疾病治疗效果。聚集诱导发光材料（AIEgens）是一种独特的有机发光体，在聚集态下具有有趣的光物理性质。在用于生物医学应用的 AIEgens 中，到目前为止，基于金属的 AIE 系统由于增强的多模态生物成像能力和治疗效果，在治疗学中显示出巨大的潜力。这个研究领域发展迅速，最近报道了许多具有治疗癌症和其他疾病的有前途的活性的合理设计系统。在这篇综述中，我们总结了基于金属的 AIE 材料在生物成像和生物治疗学中的最新进展，并解析了相关的设计策略。我们希望这篇综述能为这一不断发展的领域的发展提供新的思路。
