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增殖性玻璃体视网膜病变的药物治疗

Pharmacological therapy for proliferative vitreoretinopathy.

作者信息

Radtke N D, Weinsieder A D, Ballou R J

出版信息

Graefes Arch Clin Exp Ophthalmol. 1986;224(3):230-3. doi: 10.1007/BF02143060.

DOI:10.1007/BF02143060
PMID:3710177
Abstract

We developed an animal model in the rabbit eye with intravitreally injected heterotransplanted bovine retinal pigment epithelial cells to test a pharmacological agent which would reduce extracellular matrix formation. Results with 20 and 60 micrograms of cis-hydroxyproline showed a 48% decrease in the rate of traction retinal detachments.

摘要

我们通过向兔眼玻璃体内注射异种移植的牛视网膜色素上皮细胞建立了一种动物模型，以测试一种能够减少细胞外基质形成的药物制剂。20微克和60微克顺式羟脯氨酸的实验结果显示，牵引性视网膜脱离的发生率降低了48%。

相似文献

1
Pharmacological therapy for proliferative vitreoretinopathy.增殖性玻璃体视网膜病变的药物治疗
Graefes Arch Clin Exp Ophthalmol. 1986;224(3):230-3. doi: 10.1007/BF02143060.
2
The effect of triamcinolone acetonide on a refined experimental model of proliferative vitreoretinopathy.曲安奈德对增殖性玻璃体视网膜病变精细实验模型的作用
Am J Ophthalmol. 1985 Jun 15;99(6):686-90. doi: 10.1016/s0002-9394(14)76037-4.
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The role of breakdown of the blood-retinal barrier in cell-injection models of proliferative vitreoretinopathy.血视网膜屏障破坏在增殖性玻璃体视网膜病变细胞注射模型中的作用。
Arch Ophthalmol. 1988 Sep;106(9):1291-4. doi: 10.1001/archopht.1988.01060140451051.
4
Fluorouracil therapy for proliferative vitreoretinopathy after vitrectomy.
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Improvement in efficacy of corticosteroid therapy in an animal model of proliferative vitreoretinopathy by pretreatment.通过预处理提高增殖性玻璃体视网膜病变动物模型中皮质类固醇疗法的疗效。
Graefes Arch Clin Exp Ophthalmol. 1987;225(4):259-65. doi: 10.1007/BF02150144.
6
Biodegradable microspheres containing adriamycin in the treatment of proliferative vitreoretinopathy.含阿霉素的可生物降解微球治疗增殖性玻璃体视网膜病变。
Invest Ophthalmol Vis Sci. 1992 Oct;33(11):3125-30.
7
[Evaluation of experimental proliferative vitreoretinopathy in rabbits].
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Bovine RPE heterotransplants simulate proliferative vitreoretinopathy (PVR) in rabbits.
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Invest Ophthalmol Vis Sci. 1996 Apr;37(5):843-54.
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Proliferative vitreoretinopathy (PVR): a personal account of its pathogenesis and treatment. Proctor lecture.增殖性玻璃体视网膜病变（PVR）：对其发病机制与治疗的个人见解。普罗克特讲座
Invest Ophthalmol Vis Sci. 1988 Dec;29(12):1771-83.

引用本文的文献

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Proline metabolism and transport in retinal health and disease.脯氨酸代谢与转运在视网膜健康与疾病中的作用
Amino Acids. 2021 Dec;53(12):1789-1806. doi: 10.1007/s00726-021-02981-1. Epub 2021 Apr 19.
2
Proliferative vitreoretinopathy.增殖性玻璃体视网膜病变
Br J Ophthalmol. 1995 Oct;79(10):871-2. doi: 10.1136/bjo.79.10.871.
3
Proliferative vitreoretinopathy--is it anything more than wound healing at the wrong place?增殖性玻璃体视网膜病变——它是否仅仅是在错误部位的伤口愈合？

本文引用的文献

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TECHNICAL MODIFICATIONS IN MARAGLAS EMBEDDING.玛拉格拉斯包埋技术改进
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Intravitreal autotransplantation of fibroblasts.玻璃体内成纤维细胞自体移植
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Collagen formation by periretinal cellular membranes.视网膜周细胞膜形成胶原蛋白。
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The role of cellular proliferation in an experimental model of massive periretinal proliferation.细胞增殖在大规模视网膜周边增殖实验模型中的作用。
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