Chandler D B, Rozakis G, de Juan E, Machemer R
Am J Ophthalmol. 1985 Jun 15;99(6):686-90. doi: 10.1016/s0002-9394(14)76037-4.
Animal models of proliferative vitreoretinopathy in which the intact vitreous body is injected with large numbers of fibroblasts do not resemble the human situation. Using a refined rabbit model of proliferative vitreoretinopathy in which the vitreous is compressed and partially detached from the retinal surface and small amounts of tissue-cultured homologous fibroblasts (25,000) are scattered over the vascularized part of the retina, we reevaluated the effect of intravitreally injected triamcinolone acetonide. We found that 2 mg of the corticosteroid reduced the incidence of retinal detachments from 90% to 56%. The effect was less than in previous models with intact vitreous. Large doses of the corticosteroid had no additional effect on the reduction of retinal detachments, indicating an optimal dosage of 2 mg. The effect of the corticosteroid on neovascularization was considerable; with 8 mg it could almost be prevented (reduction from 74% to 8%).
在完整玻璃体中注射大量成纤维细胞的增殖性玻璃体视网膜病变动物模型与人类情况并不相似。我们使用一种改良的增殖性玻璃体视网膜病变兔模型，其中玻璃体被压缩并部分与视网膜表面分离，少量组织培养的同源成纤维细胞（25,000个）散布在视网膜的血管化部分，重新评估了玻璃体内注射曲安奈德的效果。我们发现2毫克这种皮质类固醇可将视网膜脱离的发生率从90%降至56%。其效果不如先前完整玻璃体模型中的效果。大剂量的皮质类固醇对减少视网膜脱离没有额外作用，表明最佳剂量为2毫克。皮质类固醇对新生血管形成的作用相当显著；使用8毫克时，几乎可以预防新生血管形成（从74%降至8%）。
