Autoimmune Diseases Research Center, Kashan University of Medical Sciences, Kashan, Iran.
Department of Obstetrics and Gynecology, Kashan University of Medical Sciences, Kashan, Iran.
Int J Clin Pract. 2023 Apr 17;2023:9528335. doi: 10.1155/2023/9528335. eCollection 2023.
Female sexual dysfunction is a common distressing problem among women, which may result from reducing circulating endogenous estrogen. L. (hop) has antioxidant, anti-inflammatory, anticancer, and estrogenic properties. Therefore, this study aimed to assess the efficacy of hop on postmenopausal sexual dysfunction.
In the current randomized clinical trial, study populations consisted of 63 postmenopausal women who were randomly categorized into two groups. In the hop group ( = 33), women received the vaginal gel containing Hop extract every day for seven days and then continued for two months, twice weekly. In the estradiol group ( = 30), women were treated with vaginal estradiol (0.625 mg) over two 28-day cycles (21 days of therapy and seven days rest). The sexual function was evaluated using the Female Sexual Function Index (FSFI) questionnaire before and after intervention.
No statistically significant differences in FSFI scores (sexual desire, sexual arousal, vaginal lubrication, satisfaction, orgasm, sexual pain, and total FSFI) ( > 0.05) were noticed after treatment between the hop and estradiol groups.
Vaginal hop was as effective as estradiol in improving the sexual dysfunction among postmenopausal women with no adverse events. This trial is registered with IRCT20210405050859N1.
女性性功能障碍是女性常见的困扰问题，可能是由于循环内源性雌激素减少所致。啤酒花具有抗氧化、抗炎、抗癌和雌激素特性。因此，本研究旨在评估啤酒花对绝经后性功能障碍的疗效。
在当前的随机临床试验中，研究人群包括 63 名绝经后妇女，她们被随机分为两组。在啤酒花组（n=33）中，妇女每天接受含有啤酒花提取物的阴道凝胶治疗，持续 7 天，然后继续治疗两个月，每周两次。在雌二醇组（n=30）中，妇女接受阴道雌二醇（0.625 毫克）治疗，为期两个 28 天周期（21 天治疗和 7 天休息）。在干预前后使用女性性功能指数（FSFI）问卷评估性功能。
治疗后，啤酒花组和雌二醇组的 FSFI 评分（性欲、性唤起、阴道润滑、满意度、性高潮、性疼痛和总 FSFI）（>0.05）无统计学显著差异。
阴道使用啤酒花与雌二醇一样有效，可以改善绝经后妇女的性功能障碍，且无不良反应。本试验已在 IRCT20210405050859N1 注册。
