Mehta Sameer K, Sunny Shashank, Nafe Zaid, Priyadarshi Kunal, Singh Prashant K
Department of General Medicine, Tata Main Hospital, Jamshedpur, IND.
Department of Internal Medicine, Tata Main Hospital, Jamshedpur, IND.
Cureus. 2023 Mar 25;15(3):e36662. doi: 10.7759/cureus.36662. eCollection 2023 Mar.
To assess the relationship between the severity of liver cirrhosis and its outcomes based on laboratory parameters, Child-Turcotte-Pugh (CTP) score, and upper gastrointestinal (UGI) endoscopy findings.
Cirrhosis is the end stage of chronic liver disease (CLD) and is characterised by progressive liver fibrosis and distortion of the liver architecture. It is a major cause of morbidity and mortality all over the world. Cirrhosis is compensated in the initial stages and later progresses to the decompensated stage with various complications. The CTP scoring system predicts mortality in patients with cirrhosis.
This retrospective study was done in the Department of Medicine and Gastroenterology of Tata Main Hospital (TMH), Jamshedpur, Jharkhand, India. It was conducted over a period of two years between 1 January 2019 and 31 December 2020, on 150 confirmed cases of cirrhosis.
The most common age group was 41-60 years (86, 57.33%) and the mean age ± standard deviation (SD) for all patients was 49.82 ± 11.63 years. In a total of 150 CLD cases, males were 96 (64%). The most common cause of CLD was alcohol (76, 50.67%). Based on presenting symptoms, most CLD patients presented with generalized weakness (144, 96.00%). The most common signs were icterus (68, 45.33%) and ascites (44, 29.33%). Most patients belonged to CTP class A (77, 51.33%), followed by CTP class B (44, 29.33%) and class C (29, 19.34%). The most common UGI endoscopy finding was portal hypertensive gastropathy (mild or severe) (135, 75%). Total deaths were 24 (16.00%), with 17 deaths (70.83%) in patients belonging to CTP class C.
CLD is a common entity in eastern India with male preponderance and affects mostly people of the middle age group. Alcohol intake is a major cause of CLD, followed by non-alcoholic fatty liver disease and chronic hepatitis B and C. A significant rise in morbidity and mortality due to alcoholic liver disease (ALD) was observed in the study and needs urgent social and medical intervention. The incidence of ALD in our study was 50.67%.
基于实验室参数、Child-Turcotte-Pugh（CTP）评分和上消化道（UGI）内镜检查结果，评估肝硬化严重程度与其预后之间的关系。
肝硬化是慢性肝病（CLD）的终末期，其特征为进行性肝纤维化和肝脏结构扭曲。它是全球发病和死亡的主要原因。肝硬化在初始阶段处于代偿期，随后会进展到失代偿期并伴有各种并发症。CTP评分系统可预测肝硬化患者的死亡率。
这项回顾性研究在印度恰尔肯德邦贾姆谢德布尔市塔塔主医院（TMH）的内科和胃肠病科进行。研究于2019年1月1日至2020年12月31日的两年期间，对150例确诊的肝硬化病例进行。
最常见的年龄组为41 - 60岁（86例，57.33%），所有患者的平均年龄±标准差（SD）为49.82 ± 11.63岁。在总共150例CLD病例中，男性有96例（64%）。CLD最常见的病因是酒精（76例，50.67%）。根据呈现的症状，大多数CLD患者表现为全身乏力（144例，96.00%）。最常见的体征是黄疸（68例，45.33%）和腹水（44例，29.33%）。大多数患者属于CTP A级（77例，51.33%），其次是CTP B级（44例，29.33%）和C级（29例，19.34%）。UGI内镜检查最常见的发现是门静脉高压性胃病（轻度或重度）（135例，75%）。总死亡人数为24例（16.00%），其中属于CTP C级的患者有17例死亡（70.83%）。
CLD在印度东部是一种常见疾病，男性居多，主要影响中年人群体。酒精摄入是CLD的主要病因，其次是非酒精性脂肪性肝病以及慢性乙型和丙型肝炎。在该研究中观察到酒精性肝病（ALD）导致的发病率和死亡率显著上升，需要紧急的社会和医疗干预。我们研究中ALD的发病率为50.67%。
