Poormolaie Neda, Mohammadi Mohammad, Mir Amirabbas, Asadi Mehrdad, Kararoudi Alireza Nouhi, Vahedian Vahid, Rashidi Mohsen, Maroufi Nazila Fathi
Department of Biochemistry, Faculty of Biology Sciences, North Tehran Branch, Islamic Azad University, Tehran, Iran.
Department of Clinical Biochemistry, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran.
Toxicol Rep. 2023 Feb 21;10:436-440. doi: 10.1016/j.toxrep.2023.02.008. eCollection 2023.
Cancer treatment is one of the main challenges of global health. For decades, researchers have been trying to find anti-cancer compounds with minimal side effects. In recent years, flavonoids, as a group of polyphenolic compounds, have attracted the attention of researchers due to their beneficial effects on health. Xanthomicrol is one of the flavonoids that has the ability to inhibit growth, proliferation, survival and cell invasion and ultimately tumor progression. Xanthomicrol, as active anti-cancer compounds, can be effective in the prevention and treatment of cancer. Therefore, the use of flavonoids can be suggested as a treatment along with other medicinal agents. It is obvious that additional investigations in cellular levels and animal models are still needed. In this review article, the effects of xanthomicrol on various cancers have been reviewed.
癌症治疗是全球健康面临的主要挑战之一。几十年来，研究人员一直在努力寻找副作用最小的抗癌化合物。近年来，黄酮类化合物作为一类多酚化合物，因其对健康的有益作用而引起了研究人员的关注。黄腐酚是具有抑制生长、增殖、存活和细胞侵袭以及最终抑制肿瘤进展能力的黄酮类化合物之一。黄腐酚作为活性抗癌化合物，可有效预防和治疗癌症。因此，可以建议将黄酮类化合物与其他药物一起作为一种治疗方法。显然，仍需要在细胞水平和动物模型上进行更多研究。在这篇综述文章中，对黄腐酚对各种癌症的影响进行了综述。
