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儿童化脓性汗腺炎。

Hidradenitis Suppurativa in Pediatric Patients.

机构信息

Department of Dermatology, George Washington School of Medicine and Health Sciences, Washington, District of Columbia.

Division of Dermatology, Children's National Hospital, Washington, District of Columbia.

出版信息

Pediatrics. 2023 May 1;151(5). doi: 10.1542/peds.2022-061049.

DOI:10.1542/peds.2022-061049
PMID:37102307
Abstract

Hidradenitis suppurativa is a chronic inflammatory skin disorder primarily affecting apocrine gland-bearing areas, including the axillae, groin, and buttocks. It is reported in up to 2% of Western populations and with increasing incidence in children and adults. Nearly one-third of hidradenitis suppurativa cases occur in pediatric patients and nearly half of patients endorse initial symptoms in childhood. To date, there are few clinical studies and guidelines for pediatric hidradenitis suppurativa. Here, we review the epidemiology, clinical presentation, comorbidities, and management of pediatric hidradenitis suppurativa. We discuss barriers contributing to delays in diagnosis and the significant physical and emotional impact of the disease on children and adolescents.

摘要

化脓性汗腺炎是一种慢性炎症性皮肤疾病,主要影响顶泌汗腺分布区域,包括腋窝、腹股沟和臀部。据报道,其在西方人群中的发病率高达 2%,且在儿童和成人中的发病率呈上升趋势。近三分之一的化脓性汗腺炎发生在儿科患者中,近一半的患者在儿童时期就出现了首发症状。迄今为止,针对儿童化脓性汗腺炎的临床研究和指南较少。在此,我们回顾了儿童化脓性汗腺炎的流行病学、临床表现、合并症和治疗。我们讨论了导致诊断延迟的障碍,以及该病对儿童和青少年的身体和心理的重大影响。

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1
Hidradenitis Suppurativa in Pediatric Patients.儿童化脓性汗腺炎。
Pediatrics. 2023 May 1;151(5). doi: 10.1542/peds.2022-061049.
2
Swiss Practice Recommendations for the Management of Hidradenitis Suppurativa/Acne Inversa.瑞士化脓性汗腺炎/反向痤疮管理实践推荐
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[Guidelines for the Management of Patients with Hidradenitis Suppurativa].[化脓性汗腺炎患者管理指南]
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Hidradenitis suppurativa: epidemiology, clinical features, associated comorbidities and treatment.化脓性汗腺炎:流行病学、临床特征、相关合并症及治疗
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Pediatric Hidradenitis Suppurativa: A Cross-Sectional Study on Clinical Features and Treatment Approaches.儿童化脓性汗腺炎:临床特征和治疗方法的横断面研究。
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Clinical Epidemiology and Management of Hidradenitis Suppurativa.《化脓性汗腺炎的临床流行病学和管理》
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Hidradenitis suppurativa in pediatric patients.儿童化脓性汗腺炎
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引用本文的文献

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Prevalence of Comorbidities Among Pediatric Patients With Hidradenitis Suppurativa: A Meta-Analysis.化脓性汗腺炎儿科患者合并症的患病率:一项荟萃分析。
JAMA Dermatol. 2025 Jun 11. doi: 10.1001/jamadermatol.2025.1565.
2
Comprehensive and Updated Algorithm of Hidradenitis Suppurativa Management from the Experts.专家提供的化脓性汗腺炎综合更新管理算法
Am J Clin Dermatol. 2025 Apr 3. doi: 10.1007/s40257-025-00940-0.
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Demographic features, clinical characteristics, and comorbid relation in hidradenitis suppurativa: a population-based study.
化脓性汗腺炎的人口统计学特征、临床特征及共病关系:一项基于人群的研究。
Front Med (Lausanne). 2025 Jan 9;11:1499509. doi: 10.3389/fmed.2024.1499509. eCollection 2024.
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Expression of nicastrin, NICD1, and Hes1 in NCSTN knockout mice: implications for hidradenitis suppurativa, Alzheimer's, and liver cancer.尼卡斯特林、NICD1和Hes1在NCSTN基因敲除小鼠中的表达:对化脓性汗腺炎、阿尔茨海默病和肝癌的影响。
Eur J Med Res. 2024 Dec 24;29(1):622. doi: 10.1186/s40001-024-02225-4.
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Relationship of vitamin D to pathogenesis and outcomes of hidradenitis suppurativa: a systematic review.维生素 D 与化脓性汗腺炎发病机制和结局的关系:系统评价。
Arch Dermatol Res. 2024 Nov 16;317(1):29. doi: 10.1007/s00403-024-03534-8.
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A Review of Hidradenitis Suppurativa in Special Populations: Considerations in Children, Pregnant and Breastfeeding Women, and the Elderly.特殊人群中的化脓性汗腺炎综述:儿童、孕妇和哺乳期妇女以及老年人的注意事项
Dermatol Ther (Heidelb). 2024 Sep;14(9):2407-2425. doi: 10.1007/s13555-024-01249-2. Epub 2024 Sep 4.
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Biologics and Small Molecule Targeted Therapies for Pediatric Alopecia Areata, Psoriasis, Atopic Dermatitis, and Hidradenitis Suppurativa in the US: A Narrative Review.美国用于儿童斑秃、银屑病、特应性皮炎和化脓性汗腺炎的生物制剂和小分子靶向疗法:一项叙述性综述
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Biosensing circulating MicroRNAs in autoinflammatory skin diseases: Focus on Hidradenitis suppurativa.自身炎症性皮肤病中生物传感循环微小RNA:聚焦化脓性汗腺炎
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