社交联系与 13 项老龄化纵向队列研究中发生轻度认知障碍、痴呆和死亡的风险。
Social connections and risk of incident mild cognitive impairment, dementia, and mortality in 13 longitudinal cohort studies of ageing.
机构信息
Centre for Healthy Brain Ageing (CHeBA), Discipline of Psychiatry and Mental Health, Faculty of Medicine and Health, UNSW Sydney, Australia.
School of Psychology and Public Health, La Trobe University Melbourne, UNSW Sydney, Australia.
出版信息
Alzheimers Dement. 2023 Nov;19(11):5114-5128. doi: 10.1002/alz.13072. Epub 2023 Apr 27.
INTRODUCTION
Previous meta-analyses have linked social connections and mild cognitive impairment, dementia, and mortality. However, these used aggregate data from North America and Europe and examined a limited number of social connection markers.
METHODS
We used individual participant data (N = 39271, M = 70.67 (40-102), 58.86% female, M = 8.43 years, M = 3.22 years) from 13 longitudinal ageing studies. A two-stage meta-analysis of Cox regression models examined the association between social connection markers with our primary outcomes.
RESULTS
We found associations between good social connections structure and quality and lower risk of incident mild cognitive impairment (MCI); between social structure and function and lower risk of incident dementia and mortality. Only in Asian cohorts, being married/in a relationship was associated with reduced risk of dementia, and having a confidante was associated with reduced risk of dementia and mortality.
DISCUSSION
Different aspects of social connections - structure, function, and quality - are associated with benefits for healthy aging internationally.
HIGHLIGHTS
Social connection structure (being married/in a relationship, weekly community group engagement, weekly family/friend interactions) and quality (never lonely) were associated with lower risk of incident MCI. Social connection structure (monthly/weekly friend/family interactions) and function (having a confidante) were associated with lower risk of incident dementia. Social connection structure (living with others, yearly/monthly/weekly community group engagement) and function (having a confidante) were associated with lower risk of mortality. Evidence from 13 longitudinal cohort studies of ageing indicates that social connections are important targets for reducing risk of incident MCI, incident dementia, and mortality. Only in Asian cohorts, being married/in a relationship was associated with reduced risk of dementia, and having a confidante was associated with reduced risk of dementia and mortality.
简介
先前的荟萃分析将社交联系与轻度认知障碍、痴呆和死亡联系起来。然而，这些研究使用了来自北美和欧洲的汇总数据，并检查了有限数量的社交联系标志物。
方法
我们使用了来自 13 项纵向老龄化研究的个体参与者数据（N=39271，M=70.67（40-102），58.86%为女性，M=8.43 年，M=3.22 年）。采用 Cox 回归模型的两阶段荟萃分析研究了社交联系标志物与我们主要结局之间的关联。
结果
我们发现良好的社交联系结构和质量与轻度认知障碍（MCI）的发病风险降低有关；社交结构和功能与痴呆和死亡的发病风险降低有关。只有在亚洲队列中，已婚/有伴侣与痴呆风险降低有关，有知己与痴呆和死亡风险降低有关。
讨论
不同方面的社交联系——结构、功能和质量——在国际上与健康老龄化的益处有关。
重点
社交联系结构（已婚/有伴侣、每周社区团体参与、每周家庭/朋友互动）和质量（从不孤独）与较低的 MCI 发病风险相关。社交联系结构（每月/每周朋友/家人互动）和功能（有知己）与较低的痴呆发病风险相关。社交联系结构（与他人同住、每年/每月/每周社区团体参与）和功能（有知己）与较低的死亡率相关。来自 13 项纵向老龄化队列研究的证据表明，社交联系是降低 MCI 发病风险、痴呆发病风险和死亡率的重要目标。只有在亚洲队列中，已婚/有伴侣与痴呆风险降低有关，有知己与痴呆和死亡风险降低有关。
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