Department of Medicinal Chemistry, College of Pharmaceutical Sciences, Suzhou University, China.
Department of Medicinal Chemistry, Jiangsu Key Laboratory of Neuropsychiatric Diseases, Suzhou University, China.
Mini Rev Med Chem. 2024;24(3):300-329. doi: 10.2174/1389557523666230427152234.
Three gaseous molecules are widely accepted as important gasotransmitters in mammalian cells, namely NO, CO and HS. Due to the pharmacological effects observed in preclinical studies, these three gasotransmitters represent promising drug candidates for clinical translation. Fluorescent probes of the gasotransmitters are also in high demand; however, the mechanisms of actions or the roles played by gasotransmitters under both physiological and pathological conditions remain to be answered. In order to bring these challenges to the attention of both chemists and biologists working in this field, we herein summarize the chemical strategies used for the design of both probes and prodrugs of these three gasotransmitters.
三种气态分子被广泛认为是哺乳动物细胞中重要的气体信号分子，即 NO、CO 和 HS。由于在临床前研究中观察到的药理学效应，这三种气体信号分子代表了具有临床转化前景的候选药物。气体信号分子的荧光探针也有很高的需求；然而，在生理和病理条件下，气体信号分子的作用机制或作用仍有待解答。为了引起该领域的化学家与生物学家的关注，我们总结了用于设计这三种气体信号分子的探针和前药的化学策略。
