Ranjana M, Sunil Dhanya
Department of Chemistry, Manipal Institute of Technology, Manipal Academy of Higher Education, Manipal, 576 104, Karnataka, India.
Department of Chemistry, Manipal Institute of Technology, Manipal Academy of Higher Education, Manipal, 576 104, Karnataka, India.
Chem Biol Interact. 2022 Aug 25;363:110022. doi: 10.1016/j.cbi.2022.110022. Epub 2022 Jun 24.
Gasotransmitters have gained significant recognition attributed to their evident biological impacts, and is accepted as a promising and less-explored area with immense research scope. The three-member family comprising of nitric oxide, carbon monoxide and hydrogen sulphide as endogenous gaseous signaling molecules have been found to elicit a plethora of crucial biological functions, spawning a new research area. The sensing of these small molecules is vital to gain deeper insights into their functions, as they can act both as a friend or a foe in mammalian systems. The initial sections of the review present the physiological and pathophysiological roles of these endogenous gas transmitters and their synergistic interactions. Further, various detection approaches, especially the usage of fascinating features of 1,8-naphthalimide as fluorescent probe in the detection and monitoring of these small signaling molecules are highlighted. The current limitations and the future scope of improving the sensing of the three gasotransmitters are also discussed.
气体递质因其明显的生物学影响而获得了广泛认可，并且被视为一个具有广阔研究范围、前景广阔但探索较少的领域。由一氧化氮、一氧化碳和硫化氢组成的三分子家族作为内源性气体信号分子，已被发现可引发大量关键的生物学功能，从而催生了一个新的研究领域。对这些小分子的传感对于深入了解它们的功能至关重要，因为它们在哺乳动物系统中既可以是“朋友”，也可以是“敌人”。综述的开头部分介绍了这些内源性气体递质的生理和病理生理作用及其协同相互作用。此外，还重点介绍了各种检测方法，特别是1,8 - 萘二甲酰亚胺作为荧光探针在检测和监测这些小信号分子方面的迷人特性的应用。还讨论了当前的局限性以及改善这三种气体递质传感的未来前景。
