Universidade de Vigo, Facultade de Ciencias, As Lagoas s/n, 32004 Ourense, Spain.
CINBIO, Universidade de Vigo, 36310 Vigo, Spain.
Food Funct. 2023 May 22;14(10):4507-4521. doi: 10.1039/d3fo00327b.
The human population is becoming old and ageing, which is related to a variety of health issues, such as Alzheimeŕs disease, obesity, diabetes, hypercholesterolemia, and some types of cancers like colorectal cancer. Furthermore, diet is a determining factor in the appearance of some of these diseases due to its direct effect at the systemic level (for instance, increase in glucose and LDL-cholesterol levels in the serum) and its influence on the composition and activity of the gut microbiota. In this context, the use of functional ingredients can be a useful strategy to prevent or even treat (in combination with drugs) some of the above-mentioned pathologies. Among the variety of functional ingredients, prebiotics have received significant attention by the scientific community. Although the already commercialized FOS are the most studied prebiotics, some efforts have been devoted to the search and evaluation of new prebiotic candidates with additional properties. In particular, in the last decade, a variety of and assays have been carried out using well isolated and characterized oligogalacturonides, demonstrating that some of them have interesting biological properties, including anticancer, antioxidant, antilipidemic, anti-obesity and anti-inflammatory activities besides prebiotic effects. This work reviews the scientific literature published recently on the production of oligogalacturonides with a special focus on their biological properties.
人口老龄化与多种健康问题相关，如阿尔茨海默病、肥胖症、糖尿病、高胆固醇血症和某些类型的癌症（如结直肠癌）。此外，由于饮食对系统水平的直接影响（例如，血清中葡萄糖和 LDL 胆固醇水平的增加）及其对肠道微生物群组成和活性的影响，饮食是这些疾病出现的决定因素之一。在这种情况下，使用功能性成分可能是预防甚至治疗（与药物联合使用）上述某些疾病的有效策略。在各种功能性成分中，益生元受到科学界的广泛关注。尽管已经商业化的 FOS 是研究最多的益生元，但人们还是努力寻找和评估具有其他特性的新的益生元候选物。特别是，在过去十年中，使用已被充分分离和鉴定的低聚半乳糖醛酸进行了多种 和 检测，结果表明其中一些具有有趣的生物学特性，除了具有益生元作用外，还具有抗癌、抗氧化、降血脂、抗肥胖和抗炎活性。本综述总结了最近关于低聚半乳糖醛酸生产的科学文献，特别关注其生物学特性。
