氨甲环酸对人卵巢癌细胞体外及体内生长的抑制作用。

The inhibitory effect of tranexamic acid on human ovarian carcinoma cell grown in vitro and in vivo.

作者信息

Kikuchi Y, Kizawa I, Oomori K, Kuki E, Kato K

出版信息

Gynecol Oncol. 1986 Jun;24(2):183-8. doi: 10.1016/0090-8258(86)90026-0.

Abstract

Effects of tranexamic acid on tumor growth were examined by using five kinds of human cultured cell lines derived from ovarian malignant tissues. An optimum inhibitory effect on cell proliferation was observed at a concentration of 10 mg/ml tranexamic acid, while replication of a clear cell carcinoma cell line (OK) was not inhibited by any concentration of tranexamic acid used in the present study. Exposure of a cystadenocarcinoma cell line (HR) to 10 mg/ml tranexamic acid for 2 hr resulted in significant growth retardation of tumors formed in nude mice. Further, tranexamic acid seemed to change the morphology of the ovarian carcinoma cells to enlarged cells with abundant cytoplasm. These results suggest that fibrinolytic factors are associated with growth of the tumor and tranexamic acid is useful as an adjuvant therapy for ovarian carcinoma.

摘要

通过使用五种源自卵巢恶性组织的人类培养细胞系，研究了氨甲环酸对肿瘤生长的影响。在氨甲环酸浓度为10 mg/ml时观察到对细胞增殖的最佳抑制作用，而本研究中使用的任何浓度的氨甲环酸均未抑制透明细胞癌细胞系（OK）的复制。将囊腺癌癌细胞系（HR）暴露于10 mg/ml氨甲环酸2小时导致裸鼠体内形成的肿瘤显著生长迟缓。此外，氨甲环酸似乎使卵巢癌细胞的形态变为细胞质丰富的大细胞。这些结果表明，纤溶因子与肿瘤生长相关，氨甲环酸可用作卵巢癌的辅助治疗。