乙醇对人脐动脉和静脉的体外作用。
Effect of ethanol on human umbilical artery and vein in vitro.
作者信息
Yang H Y, Shum A Y, Ng H T, Chen C F
出版信息
Gynecol Obstet Invest. 1986;21(3):131-5. doi: 10.1159/000298942.
In vitro effects of ethanol on human umbilical artery and vein were studied. Ethanol (0.5-2.0%) elicited a dose-dependent contractile response both in the umbilical arterial and venous strips in Krebs' and Ca2+-free Krebs' solution. In umbilical artery, but not in vein, ethanol shifted the CaCl2-induced dose-response curves to the right in a parallel manner along with a significant reduction in K+-depolarized maximal tension. These result demonstrate that ethanol can elicit a potent contractile response both in human umbilical arteries and veins and could aid in explaining why ethanol can induce the fetal alcohol syndrome.
研究了乙醇对人脐动脉和静脉的体外作用。在Krebs溶液和无Ca2+的Krebs溶液中，乙醇（0.5 - 2.0%）在脐动脉和静脉条带中均引起剂量依赖性收缩反应。在脐动脉而非静脉中，乙醇使氯化钙诱导的剂量反应曲线平行右移，同时钾离子去极化最大张力显著降低。这些结果表明，乙醇可在人脐动脉和静脉中引发强烈的收缩反应，这有助于解释乙醇为何会诱发胎儿酒精综合征。
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