Di Tommaso M, D'Alessandro A, Farruggia A, Branconi F
Biol Res Pregnancy Perinatol. 1986;7(3):111-2.
Experimentation with the "in vitro" methodology allowed the authors to study the effects of several pharmacological substances on human and animal tissue, making possible a qualitative assessment of activity, the quantitative dose-response relationships, the possible existence of specific drug receptors and the action, competitive or non-competitive, of a given antagonist. This methodology was applied to perinatology, particularly to two types of tissues: umbilical and placental vessels, arteries and veins; human and animal myometrium. Among the known circulating vasoactive substances, the authors obtained helpful results with the use of morphine, with obvious implications in obstetrical practice, that opioid substances very frequently are used to control the pains of childbirth. The experimentation with alcohol on isolated umbilical arteries and veins helps to explain the fetal alcohol syndrome. Finally, the study "in vitro" on human and animal myometrial strips gave interesting cues for the research into the regulation of the uterine contraction.
采用“体外”方法进行实验，使作者能够研究几种药理物质对人体和动物组织的影响，从而能够对活性进行定性评估、确定定量剂量反应关系、确定特定药物受体的可能存在以及给定拮抗剂的竞争性或非竞争性作用。这种方法被应用于围产医学，特别是应用于两种组织：脐血管和胎盘血管，包括动脉和静脉；人体和动物的子宫肌层。在已知的循环血管活性物质中，作者使用吗啡取得了有益的结果，这在产科实践中有明显的意义，即阿片类物质经常被用于控制分娩疼痛。用酒精对分离出的脐动脉和静脉进行实验，有助于解释胎儿酒精综合征。最后，对人体和动物子宫肌层条带进行的“体外”研究为子宫收缩调节的研究提供了有趣的线索。
