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搞错肺了!评估并提高医学数据无监督多模态编码器的可解释性。

That's the Wrong Lung! Evaluating and Improving the Interpretability of Unsupervised Multimodal Encoders for Medical Data.

作者信息

McInerney Denis Jered, Young Geoffrey, van de Meent Jan-Willem, Wallace Byron C

机构信息

Northeastern University.

Brigham and Women's Hospital.

出版信息

Proc Conf Empir Methods Nat Lang Process. 2022 Dec;2022:3626-3648.

PMID:37103483
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10124183/
Abstract

Pretraining multimodal models on Electronic Health Records (EHRs) provides a means of learning representations that can transfer to downstream tasks with minimal supervision. Recent multimodal models induce soft local alignments between image regions and sentences. This is of particular interest in the medical domain, where alignments might highlight regions in an image relevant to specific phenomena described in free-text. While past work has suggested that attention "heatmaps" can be interpreted in this manner, there has been little evaluation of such alignments. We compare alignments from a state-of-the-art multimodal (image and text) model for EHR with human annotations that link image regions to sentences. Our main finding is that the text has an often weak or unintuitive influence on attention; alignments do not consistently reflect basic anatomical information. Moreover, synthetic modifications - such as substituting "left" for "right" - do not substantially influence highlights. Simple techniques such as allowing the model to opt out of attending to the image and few-shot finetuning show promise in terms of their ability to improve alignments with very little or no supervision. We make our code and checkpoints open-source.

摘要

在电子健康记录(EHR)上预训练多模态模型提供了一种学习表征的方法,这种表征可以在最少监督的情况下迁移到下游任务。最近的多模态模型在图像区域和句子之间诱导出软局部对齐。这在医学领域特别受关注,因为对齐可能会突出图像中与自由文本中描述的特定现象相关的区域。虽然过去的工作表明注意力“热图”可以以这种方式解释,但对这种对齐的评估却很少。我们将一个用于EHR的先进多模态(图像和文本)模型的对齐与将图像区域与句子联系起来的人工注释进行比较。我们的主要发现是,文本对注意力的影响通常较弱或不直观;对齐并不能始终如一地反映基本的解剖学信息。此外,合成修改——比如将“左”替换为“右”——对突出显示的影响不大。诸如允许模型选择不关注图像以及少样本微调等简单技术,在几乎没有监督或完全没有监督的情况下,在改善对齐方面显示出了潜力。我们将代码和检查点开源。

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本文引用的文献

1
Multimodal Representation Learning via Maximization of Local Mutual Information.通过最大化局部互信息进行多模态表示学习
Med Image Comput Comput Assist Interv. 2021 Sep-Oct;12902:273-283. doi: 10.1007/978-3-030-87196-3_26. Epub 2021 Sep 21.
2
Improving Joint Learning of Chest X-Ray and Radiology Report by Word Region Alignment.通过词区域对齐改进胸部X光与放射学报告的联合学习
Mach Learn Med Imaging. 2021 Sep;12966:110-119. doi: 10.1007/978-3-030-87589-3_12. Epub 2021 Sep 21.
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Assessing the Trustworthiness of Saliency Maps for Localizing Abnormalities in Medical Imaging.评估用于医学影像中异常定位的显著性图的可信度。
Radiol Artif Intell. 2021 Oct 6;3(6):e200267. doi: 10.1148/ryai.2021200267. eCollection 2021 Nov.
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Joint Modeling of Chest Radiographs and Radiology Reports for Pulmonary Edema Assessment.用于肺水肿评估的胸部X光片与放射学报告的联合建模
Med Image Comput Comput Assist Interv. 2020 Oct;12262:529-539. doi: 10.1007/978-3-030-59713-9_51. Epub 2020 Sep 29.
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MIMIC-CXR, a de-identified publicly available database of chest radiographs with free-text reports.MIMIC-CXR,一个去标识化的、公开可用的、包含自由文本报告的胸部 X 光数据库。
Sci Data. 2019 Dec 12;6(1):317. doi: 10.1038/s41597-019-0322-0.
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Deep learning for chest radiograph diagnosis: A retrospective comparison of the CheXNeXt algorithm to practicing radiologists.深度学习在胸片诊断中的应用:CheXNeXt 算法与临床放射科医生的回顾性比较。
PLoS Med. 2018 Nov 20;15(11):e1002686. doi: 10.1371/journal.pmed.1002686. eCollection 2018 Nov.
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Variable generalization performance of a deep learning model to detect pneumonia in chest radiographs: A cross-sectional study.深度学习模型检测胸片肺炎的可变泛化性能:一项横断面研究。
PLoS Med. 2018 Nov 6;15(11):e1002683. doi: 10.1371/journal.pmed.1002683. eCollection 2018 Nov.