Department of Physical Fitness and Health, School of Sport Science, Beijing Sport University, No.48, Xinxi Road, Haidian District, Beijing, 100084, China.
Key Laboratory of Exercise and Physical Fitness, Ministry of Education, Beijing Sport University, Beijing, 100084, China.
Biochem Genet. 2023 Dec;61(6):2203-2221. doi: 10.1007/s10528-023-10385-x. Epub 2023 Apr 27.
Genetics plays a role in the development of gestational diabetes mellitus (GDM), which poses serious risks to pregnant women and their children. Several studies have demonstrated a link between GDM susceptibility and rs13266634 C/T polymorphism in SLC30A8 gene and rs1111875 C/T and rs5015480 C/T, which are located near the linkage disequilibrium block containing the IDE, HHEX, and KIF11 genes. However, the results are conflicting. Therefore, we aimed to investigate the association between susceptibility to GDM and HHEX and SLC30A8 gene polymorphisms. PubMed, Web of Science, EBSCO, CNKI, Wanfang Data, VIP, and SCOPUS were used to search for research articles. The quality of the selected literature was evaluated using the Newcastle-Ottawa scale. A meta-analysis was performed using Stata 15.1. Allelic, dominant, recessive, homozygote, and heterozygote models were used for the analysis. Nine articles with 15 studies were included. (1) Four studies about HHEX rs1111875 showed that the C allele was associated with the susceptibility to GDM; (2) three studies on HHEX rs5015480 indicated that the C allele in rs5015480 was significantly associated with GDM; (3) eight studies about SLC30A8 rs13266634 showed that the C allele was significantly associated with the susceptibility to GDM; and (4) a subgroup analysis showed that the rs5015480 polymorphism in HHEX and rs13266634 polymorphism in SLC30A8 gene were associated with GDM susceptibility in Asians. The meta-analysis provided evidence that the C allele in rs1111875 and rs5015480 in HHEX and rs13266634 in SLC30A8 can increase the risk of GDM.PROSPERO registration number CRD42022342280.
遗传学在妊娠糖尿病（GDM）的发展中起作用，它给孕妇及其子女带来严重风险。几项研究表明，GDM 易感性与 SLC30A8 基因中的 rs13266634 C/T 多态性以及位于包含 IDE、HHEX 和 KIF11 基因的连锁不平衡块附近的 rs1111875 C/T 和 rs5015480 C/T 多态性之间存在关联。然而，结果存在矛盾。因此，我们旨在研究 GDM 易感性与 HHEX 和 SLC30A8 基因多态性之间的关系。使用 PubMed、Web of Science、EBSCO、CNKI、万方数据、VIP 和 SCOPUS 搜索研究文章。使用纽卡斯尔-渥太华量表评估所选文献的质量。使用 Stata 15.1 进行荟萃分析。使用等位基因、显性、隐性、纯合子和杂合子模型进行分析。纳入了 9 篇文献共 15 项研究。（1）四项关于 HHEX rs1111875 的研究表明，C 等位基因与 GDM 易感性相关；（2）三项关于 HHEX rs5015480 的研究表明，rs5015480 中的 C 等位基因与 GDM 显著相关；（3）八项关于 SLC30A8 rs13266634 的研究表明，C 等位基因与 GDM 易感性显著相关；（4）亚组分析表明，HHEX 的 rs5015480 多态性和 SLC30A8 基因的 rs13266634 多态性与亚洲人群的 GDM 易感性相关。荟萃分析提供的证据表明，HHEX 中的 rs1111875 和 rs5015480 以及 SLC30A8 中的 rs13266634 中的 C 等位基因可以增加 GDM 的风险。PROSPERO 注册号 CRD42022342280。
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