Runyon B A, Van Epps D E
Hepatology. 1986 May-Jun;6(3):396-9. doi: 10.1002/hep.1840060311.
Serial ascitic fluid samples were obtained during diuresis in seven patients with portal hypertension-related ascites. The samples were tested for concentrations of total protein, CH100, C3 and C4 as well as for in vitro opsonic activity. These parameters were all found to increase to a statistically significant degree when the initial specimen was compared to the final specimen: total protein = 1.5 vs. 2.7 gm per dl; CH100 = 9.3 vs. 20.2 units per ml; C3 = 13.4 vs. 23.8 mg per dl; C4 = 1.9 vs. 3.6 mg per dl, and opsonic activity = 0.8 vs. 1.9 log kill. This increased opsonic activity resulted in a greater than 10-fold increase in bacterial killing. This study demonstrates that diuresis of patients with cirrhotic ascites increases the concentrations of ascitic fluid complement components and increases the opsonic activity of ascitic fluid and may help protect patients from bacterial infection of their ascites.
在七名门静脉高压相关腹水患者利尿过程中获取系列腹水样本。对样本进行总蛋白、CH100、C3和C4浓度以及体外调理活性检测。当将初始样本与最终样本进行比较时，发现所有这些参数均有统计学显著程度的升高：总蛋白 = 每分升1.5克对2.7克；CH100 = 每毫升9.3单位对20.2单位；C3 = 每分升13.4毫克对23.8毫克；C4 = 每分升1.9毫克对3.6毫克，调理活性 = 0.8对1.9对数杀灭率。这种增加的调理活性导致细菌杀灭增加超过10倍。本研究表明，肝硬化腹水患者的利尿增加了腹水补体成分的浓度，增加了腹水的调理活性，并可能有助于保护患者免受腹水细菌感染。
