HLA系统中单倍型频率及连锁不平衡参数的估计。
Estimation of haplotype frequency and linkage disequilibrium parameter in the HLA system.
作者信息
Yasuda N
出版信息
Tissue Antigens. 1978 Nov;12(5):315-22. doi: 10.1111/j.1399-0039.1978.tb01339.x.
Abstract
Conventional formulae currently employed were extended to calculate the haplotype frequency and the corresponding variance for an arbitrary number (n) of loci when unrelated individuals were investigated. A formula is presented for the variance for the degree of three locus linkage disequilibrium.
摘要
当前使用的传统公式得到了扩展，用于在研究无关个体时计算任意数量（n）基因座的单倍型频率及其相应方差。本文给出了一个关于三位点连锁不平衡程度方差的公式。
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