National Engineering Laboratory for Animal Breeding, Department of Animal Genetics and Breeding, College of Animal Science and Technology, China Agricultural University, Yuanmingyuan West Road 2, Beijing 100193, China.
Beijing Municipal General Station of Animal Science, Beijing 100107, China.
Genes (Basel). 2023 Mar 31;14(4):856. doi: 10.3390/genes14040856.
Plumage color is an artificially and naturally selected trait in domestic ducks. Black, white, and spotty are the main feather colors in domestic ducks. Previous studies have shown that black plumage color is caused by , and white plumage color is caused by . We performed a genome-wide association study (GWAS) to identify candidate genes associated with white, black, and spotty plumage in ducks. Two non-synonymous SNPs in (c.52G>A and c.376G>A) were significantly related to duck black plumage, and three SNPs in (chr13:15411658A>G, chr13:15412570T>C and chr13:15412592C>G) were associated with white plumage. Additionally, we also identified the epistatic interactions between causing loci. Some ducks with white plumage carry the c.52G>A and c.376G>A in , which also compensated for black and spotty plumage color phenotypes, suggesting that and have an epistatic effect. The locus was supposed to be an upstream gene to underlying the white, black, and spotty colors. Although the specific mechanism remains to be further clarified, these findings support the importance of epistasis in plumage color variation in ducks.
羽毛颜色是家鸭人工和自然选择的特征。黑色、白色和斑点是家鸭的主要羽色。先前的研究表明，黑色羽毛颜色是由 引起的，而白色羽毛颜色是由 引起的。我们进行了全基因组关联研究（GWAS），以鉴定与鸭的白色、黑色和斑点羽毛相关的候选基因。在 （c.52G>A 和 c.376G>A）中发现了两个非同义 SNP，它们与鸭的黑色羽毛显著相关，在 （chr13:15411658A>G、chr13:15412570T>C 和 chr13:15412592C>G）中发现了三个 SNP 与白色羽毛有关。此外，我们还鉴定了导致这些表型的基因座之间的上位性相互作用。一些具有白色羽毛的鸭子携带 中的 c.52G>A 和 c.376G>A，这也补偿了黑色和斑点羽毛的颜色表型，表明 和 存在上位性效应。 位点被认为是白色、黑色和斑点颜色背后的一个上游基因 。尽管具体机制仍有待进一步阐明，但这些发现支持了上位性在家鸭羽毛颜色变异中的重要性。
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