Wu Youtu, Li Chuzhong, Zhang Huifang, Wang Guoqin, Jing Linkai, Yi Guo, Yang Xuejun, Gui Songbai, Gao Hua, Zhang Yazhuo, Wang Guihuai, Bai Jiwei
Neurosurgical Department, Beijing Tsinghua Changgung Hospital, Beijing 102218, China.
Beijing Neurosurgery Institute, Capital Medical University, Beijing 100070, China.
Healthcare (Basel). 2023 Apr 14;11(8):1135. doi: 10.3390/healthcare11081135.
Chordomas are very rare malignant bone tumors. Following surgery, their effects on neurological, physical, psychological, social, and emotional functioning are substantial and can have a major impact on a patients' quality of life (QOL). In this survey, we aimed to characterize the postoperation health-related QOL and emotional problem in patients with chordoma using the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire 30 (EORTC QLQ-C30) and Hamilton Depression Rating Scale (HAMD). The cohort included 100 patients who underwent resection surgery between 2014 and 2020. Being single or divorced, living in a rural area, receiving a diagnosis of sacrococcygeal chordoma, Karnofsky performance status (KPS) ≤ 70, and weight loss were associated with increased likelihood of depression ( < 0.05). Patients who were single or divorced, with KPS ≤ 70, and experiencing weight loss had a higher likelihood of a worse QOL ( < 0.05). The uni- and multivariate logistic regression analyses indicated that the KPS level ( = 0.000) and postoperative radiation therapy ( = 0.009) were related to depression; marital status ( = 0.029), KPS level ( = 0.006), and tumor location ( = 0.033) were related to worse QOL. Certain characteristics placed patients with chordoma at increased risk of emotional problems, which are associated with a lowered QOL and a higher symptom burden. Further knowledge regarding emotional problems is key to improving the QOL for patients with chordoma.
脊索瘤是非常罕见的恶性骨肿瘤。手术后，它们对神经、身体、心理、社交和情感功能的影响很大，会对患者的生活质量（QOL）产生重大影响。在这项调查中，我们旨在使用欧洲癌症研究与治疗组织生活质量问卷30（EORTC QLQ-C30）和汉密尔顿抑郁量表（HAMD）来描述脊索瘤患者术后与健康相关的生活质量和情感问题。该队列包括100名在2014年至2020年间接受切除手术的患者。单身或离异、生活在农村地区、被诊断为骶尾部脊索瘤、卡诺夫斯基表现状态（KPS）≤70以及体重减轻与抑郁可能性增加相关（<0.05）。单身或离异、KPS≤70以及体重减轻的患者生活质量较差的可能性更高（<0.05）。单因素和多因素逻辑回归分析表明，KPS水平（=0.000）和术后放疗（=0.009）与抑郁有关；婚姻状况（=0.029）、KPS水平（=0.006）和肿瘤位置（=0.033）与较差的生活质量有关。某些特征使脊索瘤患者出现情感问题的风险增加，这些情感问题与较低的生活质量和较高的症状负担相关。进一步了解情感问题是改善脊索瘤患者生活质量的关键。
