Shenzhen Engineering Labortaory for Marine Algal Biotechnology, Longhua Innovation Institute for Biotechnology, College of Life Sciences and Oceanography, Lihu Campus of Shenzhen University, Shenzhen 518055, China.
College of Physics and Optoelectronic Engineering, Canghai Campus of Shenzhen University, Shenzhen 518060, China.
Int J Mol Sci. 2023 Apr 11;24(8):7076. doi: 10.3390/ijms24087076.
One important feature of tumour development is the regulatory role of metabolic plasticity in maintaining the balance of mitochondrial oxidative phosphorylation and glycolysis in cancer cells. In recent years, the transition and/or function of metabolic phenotypes between mitochondrial oxidative phosphorylation and glycolysis in tumour cells have been extensively studied. In this review, we aimed to elucidate the characteristics of metabolic plasticity (emphasizing their effects, such as immune escape, angiogenesis migration, invasiveness, heterogeneity, adhesion, and phenotypic properties of cancers, among others) on tumour progression, including the initiation and progression phases. Thus, this article provides an overall understanding of the influence of abnormal metabolic remodeling on malignant proliferation and pathophysiological changes in carcinoma.
肿瘤发生的一个重要特征是代谢可塑性在维持癌细胞中线粒体氧化磷酸化和糖酵解平衡方面的调节作用。近年来，肿瘤细胞中线粒体氧化磷酸化和糖酵解之间的代谢表型的转变和/或功能已经得到了广泛的研究。在这篇综述中，我们旨在阐明代谢可塑性的特征（强调其对肿瘤进展的影响，如免疫逃避、血管生成迁移、侵袭性、异质性、黏附以及癌症的表型特性等），包括起始和进展阶段。因此，本文提供了对异常代谢重塑对癌恶性增殖和病理生理变化影响的全面理解。
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