Huang Jia-Hui, Chen Shu-Huey, Liao Yu-Mei, Kao Yu-Chien, Ho Wan-Ling, Chang Hsi, Tsai Min-Lan, Lee Hsin-Lun, Kuo Chia-Chun, Tseng Sung-Hui, Chang Chia-Yau, Hsieh Kevin Li-Chun, Lu Long-Sheng, Chen Yin-Ju, Chiou Jeng-Fong, Hsieh Tsung-Han, Liu Yun-Ru, Hsu Wayne, Li Wei-Tang, Wu Yu-Chung, Wu Wei-Ciao, Wang Jinn-Li, Tsai Jia-Jia, Terashima Keita, Kiyotani Chikako, Wong Tai-Tong, Miser James S, Liu Yen-Lin
Department of Pediatrics, Taipei Medical University Hospital, Taipei 110, Taiwan.
Department of Pediatrics, School of Medicine, College of Medicine, Taipei Medical University, Taipei 110, Taiwan.
J Pers Med. 2023 Apr 14;13(4):668. doi: 10.3390/jpm13040668.
Twelve Asian patients with sarcoma received interval-compressed (ic-) chemotherapy scheduled every 14 days with a regimen of vincristine (2 mg/m), doxorubicin (75 mg/m), and cyclophosphamide (1200-2200 mg/m) (VDC) alternating with a regimen of ifosfamide (9000 mg/m) and etoposide (500 mg/m) (IE), with filgrastim (5-10 mcg/kg/day) between cycles. Carboplatin (800 mg/m) was added for CIC-rearranged sarcoma. The patients were treated with 129 cycles of ic-VDC/IE with a median interval of 19 days (interquartile range [IQR], 15-24 days. Median nadirs (IQR) were neutrophil count, 134 (30-396) × 10/L at day 11 (10-12), recovery by day 15 (14-17) and platelet count, 35 (23-83) × 10/L at day 11 (10-13), recovery by day 17 (14-21). Fever and bacteremia were observed in 36% and 8% of cycles, respectively. The diagnoses were Ewing sarcoma (6), rhabdomyosarcoma (3), myoepithelial carcinoma (1), malignant peripheral nerve sheath tumor (1), and Sarcoma (1). Seven of the nine patients with measurable tumors responded (one CR and six PR). Interval-compressed chemotherapy is feasible in the treatment of Asian children and young adults with sarcomas.
12例亚洲肉瘤患者接受每14天一次的间隔压缩（ic-）化疗，化疗方案为长春新碱（2mg/m）、阿霉素（75mg/m）和环磷酰胺（1200 - 2200mg/m）（VDC）与异环磷酰胺（9000mg/m）和依托泊苷（500mg/m）（IE）交替使用，周期之间使用非格司亭（5 - 10mcg/kg/天）。对于CIC重排的肉瘤，添加卡铂（800mg/m）。患者接受了129个周期的ic-VDC/IE治疗，中位间隔为19天（四分位间距[IQR]，15 - 24天）。中位最低点（IQR）为中性粒细胞计数，第11天（10 - 12）时为134（30 - 396）×10⁹/L，第15天（14 - 17）恢复；血小板计数，第11天（10 - 13）时为35（23 - 83）×10⁹/L，第17天（14 - 21）恢复。分别在36%和8%的周期中观察到发热和菌血症。诊断为尤因肉瘤（6例）、横纹肌肉瘤（3例）、肌上皮癌（1例）、恶性周围神经鞘瘤（1例）和肉瘤（1例）。9例有可测量肿瘤的患者中有7例有反应（1例完全缓解和6例部分缓解）。间隔压缩化疗在治疗亚洲儿童和年轻成人肉瘤方面是可行的。
