Kimbara Shiro, Imamura Yoshinori, Kiyota Naomi, Takakura Hidetomo, Matsumoto Sakuya, Koyama Taiji, Fujishima Yoshimi, Funakoshi Yohei, Toyoda Masanori, Hirose Takanori, Kanzawa Maki, Kawamoto Teruya, Hara Hitomi, Minami Hironobu
Department of Medical Oncology/Hematology, Kobe University Hospital, Kobe, Hyogo 650-0017, Japan.
Kobe University Hospital Cancer Center, Kobe University Hospital, Kobe, Hyogo 650-0017, Japan.
Mol Clin Oncol. 2021 Apr;14(4):68. doi: 10.3892/mco.2021.2230. Epub 2021 Feb 8.
Capicua transcriptional repressor -rearranged sarcoma is an Ewing-like sarcoma with an aggressive clinical course and poor prognosis. No standard treatment has been established. The present study describes a case of -rearranged sarcoma with lung metastases developing in a 24-year-old woman as a therapy-associated malignancy following chemotherapy for anaplastic large cell lymphoma at nine years old. This was treated with palliative regimens used for Ewing sarcoma. The patient achieved disease control for one year. Of note, ifosfamide and etoposide (IE), which were used as a second line treatment lead to a partial response. The case described in the present study indicated that treatment with Ewing regimens is a reasonable option for patients with metastatic -rearranged sarcoma, including those with a second malignant case.
Capicua转录抑制因子重排肉瘤是一种临床过程侵袭性强、预后差的尤因样肉瘤。目前尚未确立标准治疗方法。本研究描述了一例24岁女性发生肺转移的重排肉瘤病例，该病例是其9岁时接受间变性大细胞淋巴瘤化疗后发生的治疗相关恶性肿瘤。采用了用于尤因肉瘤的姑息治疗方案。患者病情得到了一年的控制。值得注意的是，作为二线治疗使用的异环磷酰胺和依托泊苷（IE）导致了部分缓解。本研究中描述的病例表明，对于转移性重排肉瘤患者，包括那些患有第二原发性恶性肿瘤的患者，采用尤因治疗方案是一种合理的选择。
