Sunjic Roguljic Veridijana, Roguljic Luka, Kovacic Vedran, Jukic Ivana
Surgery Department, Plastic, Reconstructive and Aesthetic Surgery with Burn Care Division, University Hospital of Split, 21000 Split, Croatia.
Surgery Department, Orthopaedics and Traumatology Division, University Hospital of Split, 21000 Split, Croatia.
J Clin Med. 2023 Apr 14;12(8):2864. doi: 10.3390/jcm12082864.
Carpal tunnel syndrome (CTS) is the most common peripheral neuropathy caused by compression of the median nerve in the carpal tunnel. The presented study aimed to evaluate clinical outcomes by comparing two techniques of wound closure following carpal tunnel surgery in subjects randomized to the application of tissue adhesive or sutures.
From April 2022 to December 2022, a single-center randomized prospective trial was conducted at the University Hospital of Split in Croatia. The study participants consisted of 100 patients (70 females) aged 61.56 ± 12.03 years, randomly assigned to suture-based wound closure ( = 50) or tissue adhesive-based wound closure ( = 50) with two-component skin adhesive Glubran Tiss 2. The outcomes were assessed postoperatively during the follow-up period at intervals of 2, 6, and 12 weeks. A scar assessment was performed using the POSAS (Patient and Observer Scar Assessment Scale) and cosmetic VAS (Visual Analog Scale). The VNRS (Verbal Number Rating Scale) was used to assess pain.
There were significant differences between glue-based wound closure and suture-based wound closure at 2-week and 6-week intervals after the surgery on the POSAS and cosmetic-VAS scales (better aesthetic effect with glue-based wound closure technique where noticed), with less postoperative pain at the same intervals. With the 12-week interval, differences in outcomes were insignificant.
This trial demonstrated that cyanoacrylate-based adhesion mixtures might be possibly superior in the short term in terms of cosmetic appearance and discomfort compared to conventional skin suturing techniques for the closing of surgical wounds following open CTS decompression, but there was no difference between both procedures in the long term.
腕管综合征（CTS）是最常见的由腕管内正中神经受压引起的周围神经病变。本研究旨在通过比较腕管手术后两种伤口闭合技术（随机应用组织粘合剂或缝线）来评估临床结果。
2022年4月至2022年12月，在克罗地亚斯普利特大学医院进行了一项单中心随机前瞻性试验。研究参与者包括100名年龄为61.56±12.03岁的患者（70名女性），随机分为缝线伤口闭合组（n = 50）或使用双组分皮肤粘合剂Glubran Tiss 2的组织粘合剂伤口闭合组（n = 50）。在术后随访期间，分别于2周、6周和12周对结果进行评估。使用POSAS（患者和观察者瘢痕评估量表）和美容视觉模拟量表（VAS）进行瘢痕评估。使用言语数字评定量表（VNRS）评估疼痛。
在术后2周和6周时，基于粘合剂的伤口闭合和基于缝线的伤口闭合在POSAS和美容VAS量表上存在显著差异（注意到基于粘合剂的伤口闭合技术具有更好的美学效果），且在相同时间间隔内术后疼痛较轻。在12周时，结果差异不显著。
该试验表明，与传统皮肤缝合技术相比，基于氰基丙烯酸酯的粘合混合物在开放性CTS减压术后手术伤口闭合的短期美容外观和不适感方面可能更具优势，但从长期来看，两种方法之间没有差异。
