Sagaro Getu Gamo, Amenta Francesco
Clinical Research, Telemedicine and Telepharmacy Center, School of Medicinal and Health Products Sciences, University of Camerino, 62032 Camerino, Italy.
J Clin Med. 2023 Apr 14;12(8):2875. doi: 10.3390/jcm12082875.
Globally, stroke is the second leading cause of death and disability. In different studies conducted previously, the choline-containing phospholipids citicoline and choline alphoscerate have been proposed as adjuvants in the treatment of acute strokes. A systematic review was conducted to provide updated information on the effects of citicoline and choline alphoscerate in patients with acute and hemorrhagic strokes.
PubMed/Medline, Scopus, and Web of Science were searched to identify relevant materials. Data were pooled, and odds ratios (OR) were reported for binary outcomes. Using mean differences (MD), we evaluated continuous outcomes.
A total of 1460 studies were reviewed; 15 studies with 8357 subjects met the eligibility criteria and were included in the analysis. In our study, citicoline treatment did not result in improved neurological function (NIHSS < 1, OR = 1.05; 95% confidence interval (CI): 0.87-1.27) or functional recovery (mRS < 1, OR = 1.36; 95% CI: 0.99-1.87) in patients with acute stroke. Choline alphoscerate improved neurological function and functional recovery in stroke patients based on the Mathew's scale and the Mini-Mental State Examination (MMSE).
Citicoline did not improve the neurological or functional outcomes in acute stroke patients. In contrast, choline alphoscerate improved neurological function and functional recovery and reduced dependency in stroke patients.
在全球范围内，中风是导致死亡和残疾的第二大主要原因。在先前进行的不同研究中，含胆碱的磷脂胞磷胆碱和阿法甘油磷酸胆碱已被提议作为急性中风治疗的佐剂。进行了一项系统评价，以提供关于胞磷胆碱和阿法甘油磷酸胆碱对急性和出血性中风患者影响的最新信息。
检索了PubMed/Medline、Scopus和科学网以识别相关材料。汇总数据，并报告二元结局的比值比（OR）。使用均值差（MD）评估连续结局。
共审查了1460项研究；15项研究共8357名受试者符合纳入标准并被纳入分析。在我们的研究中，胞磷胆碱治疗并未改善急性中风患者的神经功能（美国国立卫生研究院卒中量表[NIHSS]<1，OR=1.05；95%置信区间[CI]：0.87-1.27）或功能恢复（改良Rankin量表[mRS]<1，OR=1.36；95%CI：0.99-1.87）。阿法甘油磷酸胆碱根据马修斯量表和简易精神状态检查表（MMSE）改善了中风患者的神经功能和功能恢复。
胞磷胆碱未改善急性中风患者的神经或功能结局。相比之下，阿法甘油磷酸胆碱改善了中风患者的神经功能和功能恢复，并减少了其依赖性。
