De Luca Pietro, D'Ascanio Luca, Cingolani Cristina, Latini Gino, Grigaliute Egle, Di Mauro Paola, Ralli Massimo, La Mantia Ignazio, Di Stadio Arianna
Department of Otolaryngology, San Giovanni-Addolorata Hospital, 00100 Rome, Italy.
Otolaryngology Department, AORMN (Azienda Ospedali Riuniti Marche Nord), 61032 Fano, Italy.
J Clin Med. 2023 Apr 18;12(8):2929. doi: 10.3390/jcm12082929.
Although chronic sinusitis widely affects the adult population, the treatments currently used did not always satisfactorily solve the symptoms. Traditional therapy with steroids and antibiotics presents risks and benefits and the new drugs, i.e., monoclonal antibody, are valid solutions despite being quite expensive. Natural molecules could be a valid treatment that combines good efficacy and low price. We conducted a case -control study to evaluate the benefit of an oral supplement with Ribes nigrum, Boswellia serrata, Bromelain and Vitamin D on chronic sinusitis symptoms. 60 patients were randomly assigned to one of the three groups: control using nasal steroids only, treatment 1 using nasal steroid and 1 dose of the oral supplement for 30 days and treatment 2 in which patients used nasal steroid and two oral supplement doses daily for 15 days. Conditions of the nasal mucosa and a blood sample (WBC, IgE and CRP) were analyzed at T0, T1 (15 days after treatment) and T2 (30 days after treatment. Patients treated with the supplement improved their nasal findings (hyperemia of mucosa and rhinorrhea) with statistically significant differences from the control. Our preliminary data suggest that the addition of supplement containing Ribes nigrum, Boswellia serrata, Vitamin D and Bromelain to the traditional local therapy (nasal spray with cortisone) can be a supporting therapy to modulate the local inflammation in the nose in patients affected by chronic sinusitis.
尽管慢性鼻窦炎在成年人群中广泛存在，但目前使用的治疗方法并不总能令人满意地解决症状。传统的类固醇和抗生素治疗有风险也有好处，而新药，即单克隆抗体，尽管价格昂贵却是有效的解决方案。天然分子可能是一种兼具良好疗效和低价格的有效治疗方法。我们进行了一项病例对照研究，以评估口服含有黑醋栗、乳香、菠萝蛋白酶和维生素D的补充剂对慢性鼻窦炎症状的益处。60名患者被随机分为三组之一：仅使用鼻用类固醇的对照组、使用鼻用类固醇和一剂口服补充剂持续30天的治疗组1，以及患者使用鼻用类固醇和每日两剂口服补充剂持续15天的治疗组2。在T0、T1（治疗后15天）和T2（治疗后30天）分析鼻黏膜状况和血样（白细胞、免疫球蛋白E和C反应蛋白）。接受补充剂治疗的患者改善了他们的鼻腔症状（黏膜充血和流鼻涕），与对照组相比有统计学上的显著差异。我们的初步数据表明，在传统局部治疗（用可的松鼻喷雾剂）中添加含有黑醋栗、乳香、维生素D和菠萝蛋白酶的补充剂可以作为一种辅助治疗，调节慢性鼻窦炎患者鼻腔的局部炎症。
