Unit of Otolaryngology, Department of General Surgery and Medical-Surgical Specialties, University of Catania, Catania, Italy.
Department of Otolaryngology, University of Foggia, Foggia, Italy.
J Biol Regul Homeost Agents. 2020 Nov-Dec;34(6 Suppl. 1):27-34.
Rhinosinusitis (RS) affects the nose and the paranasal sinus and is characterized by nasal and systemic symptoms. It may be classified as acute or chronic, based on duration. Rhinosinusitis may be clinically suspected, but the diagnosis is usually based on the endoscopy. Antibiotic therapy is frequently used for RS patients in clinical practice. However, antibiotics often induce intestinal dysbiosis associated with some clinical problems and respiratory microbiota impairment. The current clinical experience was conducted in patients with pharyngotonsillitis and treated with antibiotics. A one-month course of a probiotic mixture (Abincol® containing Lactobacillus plantarum LP01 (1 billion of living cells), Lactobacillus lactis subspecies cremoris LLC02 (800 million living cells), and Lactobacillus delbrueckii LDD01 (200 million living cells), was prescribed in the Group A, and was compared with no addon treatment, such as the Group B. Patients were evaluated at baseline (T0), at the end of antibiotic treatment (T1), at the end of probiotic course (T2), and at the end of 3-month follow-up (T3).
鼻窦炎（RS）影响鼻子和鼻窦，其特征为鼻部和全身症状。其可根据持续时间分类为急性或慢性鼻窦炎。鼻窦炎可能被临床怀疑，但诊断通常基于内镜检查。抗生素疗法在临床上常用于 RS 患者。然而，抗生素经常会引起与一些临床问题和呼吸道微生物群损伤相关的肠道菌群失调。目前的临床经验是在患有咽扁桃体炎并接受抗生素治疗的患者中进行的。在 A 组中，开了一个月疗程的益生菌混合物（含有植物乳杆菌 LP01（10 亿活细胞）、乳双歧杆菌亚种嗜热链球菌 LLC02（8 亿活细胞）和德氏乳杆菌 LDD01（2 亿活细胞）的 Abincol®），并与无添加治疗（如 B 组）进行比较。患者在基线（T0）、抗生素治疗结束时（T1）、益生菌疗程结束时（T2）和 3 个月随访结束时（T3）进行评估。
