Mihajlovic Sladjana, Nikolic Dejan, Milicic Biljana, Santric-Milicevic Milena, Glushkova Natalya, Nurgalieva Zhansaya, Lackovic Milan
University Hospital "Dragisa Misovic", Heroja Milana Tepica 1, 11000 Belgrade, Serbia.
Faculty of Medicine, University of Belgrade, 11000 Belgrade, Serbia.
J Clin Med. 2023 Apr 18;12(8):2936. doi: 10.3390/jcm12082936.
During the COVID-19 pandemic, a possible overlap of obesity and COVID-19 infection has raised concerns among patients and healthcare professionals about protecting pregnant women from developing a severe infection and unwanted pregnancy outcomes. The aim of this study was to evaluate the associations of body mass index with clinical, laboratory, and radiology diagnostic parameters as well as pregnancy complications and maternal outcomes in pregnant patients with COVID-19.
Clinical status, laboratory, and radiology diagnostic parameters and pregnancy outcomes were analyzed for pregnant women hospitalized between March 2020 and November 2021 in one tertiary-level university clinic in Belgrade, Serbia, due to infection with SARS-CoV-2. Pregnant women were divided into the three sub-groups according to their pre-pregnancy body mass index. For testing the differences between groups, a two-sided -value <0.05 (the Kruskal-Wallis and ANOVA tests) was considered statistically significant.
Out of 192 hospitalized pregnant women, obese pregnant women had extended hospitalizations, including ICU duration, and they were more likely to develop multi-organ failure, pulmonary embolism, and drug-resistant nosocomial infection. Higher maternal mortality rates, as well as poor pregnancy outcomes, were also more likely to occur in the obese group of pregnant women. Overweight and obese pregnant women were more likely to develop gestational hypertension, and they had a higher grade of placental maturity.
Obese pregnant women hospitalized due to COVID-19 infection were more likely to develop severe complications.
在新冠疫情期间，肥胖与新冠病毒感染可能存在的重叠情况引发了患者和医护人员对保护孕妇免受严重感染及不良妊娠结局影响的担忧。本研究的目的是评估体重指数与新冠病毒感染孕妇的临床、实验室及放射学诊断参数、妊娠并发症和孕产妇结局之间的关联。
对2020年3月至2021年11月期间因感染新冠病毒在塞尔维亚贝尔格莱德一家三级大学诊所住院的孕妇的临床状况、实验室及放射学诊断参数和妊娠结局进行了分析。孕妇根据孕前体重指数分为三个亚组。为检验组间差异，双侧p值<0.05（Kruskal-Wallis检验和方差分析）被认为具有统计学意义。
在192名住院孕妇中，肥胖孕妇的住院时间延长，包括重症监护病房停留时间，且她们更易发生多器官功能衰竭、肺栓塞和耐多药医院感染。肥胖孕妇组的孕产妇死亡率更高，不良妊娠结局的发生率也更高。超重和肥胖孕妇更易发生妊娠期高血压，且胎盘成熟度更高。
因新冠病毒感染住院的肥胖孕妇更易发生严重并发症。
