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妊娠及产褥期肺栓塞

Pulmonary embolism in pregnancy and the puerperium.

作者信息

Lao Terence T

机构信息

Department of Obstetrics & Gynaecology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong.

出版信息

Best Pract Res Clin Obstet Gynaecol. 2022 Dec;85(Pt A):96-106. doi: 10.1016/j.bpobgyn.2022.06.003. Epub 2022 Jun 24.

Abstract

Pulmonary embolism (PE) in pregnant women appears to be increasing. This could be related in part to improved health care allowing more women with risk factors to conceive, as well as increase in the high-risk groups which include pregnancies conceived on artificial reproductive technology, advancing maternal age, obesity, and caesarean deliveries. Prevention and early diagnosis with prompt effective treatment can reduce maternal mortality and improve pregnancy outcome, so that obstetricians should be on the lookout for venous thrombosis and PE, especially when in the majority of cases, risk factors only start to emerge or develop in the course of pregnancy and delivery. Management includes accurate diagnosis with ventilation/perfusion scan and CT pulmonary angiography, followed by effective anticoagulation and more aggressive measures such as thrombolysis as indicated, together with general supportive measures. Postpartum management should cover subsequent health issues, including breastfeeding, contraception, mood changes, and recurrence in subsequent pregnancies.

摘要

孕妇肺栓塞(PE)的发病率似乎在上升。这可能部分归因于医疗保健水平的提高,使得更多有风险因素的女性能够怀孕,同时高危人群也在增加,其中包括通过人工生殖技术受孕的孕妇、孕产妇年龄增长、肥胖以及剖宫产。预防和早期诊断并及时进行有效治疗可以降低孕产妇死亡率并改善妊娠结局,因此产科医生应留意静脉血栓形成和肺栓塞,尤其是在大多数情况下,风险因素仅在妊娠和分娩过程中才开始出现或发展。管理措施包括通过通气/灌注扫描和CT肺动脉造影进行准确诊断,随后进行有效的抗凝治疗,并根据需要采取更积极的措施,如溶栓治疗,同时辅以一般支持性措施。产后管理应涵盖后续的健康问题,包括母乳喂养、避孕、情绪变化以及后续妊娠中的复发情况。

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