DeMarco Benjamin, MacRosty Christina R
Division of Pulmonary Diseases and Critical Care Medicine, Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27514, USA.
Section of Interventional Pulmonology and Pulmonary Oncology, Division of Pulmonary Diseases and Critical Care Medicine, Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27514, USA.
Life (Basel). 2023 Apr 18;13(4):1036. doi: 10.3390/life13041036.
Chronic Obstructive Pulmonary Disease (COPD) is a highly prevalent and morbid disease marked by irreversible structural changes in the lungs. Bronchoscopic therapies have significantly expanded the treatment armamentarium for patients with persistent symptoms by reducing the physiologic detriments of hyperinflation in a less invasive fashion than surgical lung volume reduction. The spectrum of bronchoscopic techniques to reduce hyperinflation includes endobronchial valves, coils, thermal ablation, and biologic sealants. Other therapies focus on reducing parasympathetic tone and mucus hypersecretion and include targeted lung denervation, bronchial rheoplasty, and cryospray techniques. In this article, we will review the variety of techniques for bronchoscopic lung volume reduction, both established and investigational, along with their respective benefits and complications and will briefly review other investigational therapies for COPD.
慢性阻塞性肺疾病（COPD）是一种高度流行且具有高致病性的疾病，其特征为肺部不可逆的结构改变。支气管镜治疗通过以比外科肺减容术侵入性更小的方式减少肺过度充气的生理损害，显著扩大了对有持续症状患者的治疗手段。减少肺过度充气的支气管镜技术包括支气管内瓣膜、线圈、热消融和生物密封剂。其他治疗方法侧重于降低副交感神经张力和黏液分泌过多，包括靶向肺去神经支配、支气管成形术和冷冻喷雾技术。在本文中，我们将回顾已确立的和正在研究的各种支气管镜肺减容技术，以及它们各自的益处和并发症，并将简要回顾COPD的其他正在研究的治疗方法。
