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长期食用甜蜜素和糖精对健康个体和 2 型糖尿病患者生化参数的影响。

Impact of Long-Term Cyclamate and Saccharin Consumption on Biochemical Parameters in Healthy Individuals and Type 2 Diabetes Mellitus Patients.

机构信息

Department of Medicinal Chemistry, College of Pharmacy, University of Duhok, Duhok 1006, AJ, Iraq.

出版信息

Medicina (Kaunas). 2023 Apr 3;59(4):698. doi: 10.3390/medicina59040698.

DOI:10.3390/medicina59040698
PMID:37109657
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10146554/
Abstract

BACKGROUND

Previous studies on saccharin and cyclamate were either limited to experimental animals or lacked evaluation of their long-term consumption effects in humans.

OBJECTIVES

This study evaluated the effect of chronic consumption of saccharin and cyclamate on biochemical parameters in healthy individuals and patients with type 2 diabetes mellitus.

MATERIAL AND METHODS

Healthy and diabetic individuals were classified into two groups based on whether they consumed sweeteners or not. The participants were classified according to the amount of sweetener consumed per day and duration of consumption. Serum catalase activity, peroxynitrite, ceruloplasmin, and malondialdehyde concentrations were determined. Glycated hemoglobin, fasting glucose, creatinine, alanine transaminase, and lipid profile were also evaluated. The results suggest that saccharin and cyclamate increased HbA1C (+11.16%), MDA (+52.38%), TG (+16.74%), LDL (+13.39%), and TC/HDL (+13.11%) in healthy volunteers. Diabetic patients consuming sweeteners showed increased FSG (+17.51%), ceruloplasmin (+13.17%), and MDA (+8.92%). Diabetic patients showed a positive correlation between the number of tablets consumed per day with FSG and serum creatinine. A positive correlation was found between the duration of sweetener consumption and FSG as well as TG.

CONCLUSION

Consumption of saccharin and cyclamate affected biochemical parameters related to metabolic functions in a time and dose-dependent manner and appear to increase oxidative stress in healthy and diabetic type 2 patients.

摘要

背景

先前关于糖精和环己基氨基磺酸钠的研究要么局限于实验动物，要么缺乏对其在人类中长期摄入影响的评估。

目的

本研究评估了慢性摄入糖精和环己基氨基磺酸钠对健康个体和 2 型糖尿病患者生化参数的影响。

材料和方法

根据是否摄入甜味剂，将健康个体和糖尿病患者分为两组。根据每天摄入的甜味剂量和摄入持续时间对参与者进行分类。测定血清过氧化氢酶活性、过氧亚硝酸盐、铜蓝蛋白和丙二醛浓度。还评估了糖化血红蛋白、空腹血糖、肌酐、丙氨酸氨基转移酶和血脂谱。结果表明，糖精和环己基氨基磺酸钠使健康志愿者的 HbA1C（增加 11.16%）、MDA（增加 52.38%）、TG（增加 16.74%）、LDL（增加 13.39%）和 TC/HDL（增加 13.11%）升高。摄入甜味剂的糖尿病患者显示 FSG（增加 17.51%）、铜蓝蛋白（增加 13.17%）和 MDA（增加 8.92%）增加。糖尿病患者发现每日服用片剂数量与 FSG 和血清肌酐之间呈正相关。甜味剂摄入时间与 FSG 以及 TG 之间也存在正相关。

结论

糖精和环己基氨基磺酸钠的摄入以时间和剂量依赖的方式影响与代谢功能相关的生化参数，并且似乎会增加健康和 2 型糖尿病患者的氧化应激。

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