Bagby G J, Johnson J L, Bennett B W, Shepherd R E
J Appl Physiol (1985). 1986 May;60(5):1623-7. doi: 10.1152/jappl.1986.60.5.1623.
Voluntary exercise of rats in freely rotating work wheels has been extensively used, but muscle adaptations that result from such exercise training are poorly documented. The purpose of this study was to determine whether the exercise performed by voluntarily active rats would increase succinate dehydrogenase or lipoprotein lipase activities in the soleus muscle (SM) or the red portion of the vastus lateralis muscle (RV). In SM the activities of these two enzymes were not increased after 7 or 16 wk of voluntary exercise. Succinate dehydrogenase activity in RV was moderately increased after 7 and 16 wk of voluntary activity (P less than 0.05). Substantial increases occurred in RV lipoprotein lipase activity (P less than 0.01). The increase in RV lipoprotein lipase activity was positively related to distance run by the rats. The results indicate that only small muscle-dependent increases in mitochondrial enzymes occur in rats allowed to exercise voluntarily in rodent work wheels. Voluntary exercise training induced a selective increase in lipoprotein lipase activity in a muscle containing a high percentage of fast-twitch red fibers, a response absent in a muscle containing a predominance of slow-twitch red fibers. It is unlikely that this differential response can be explained by exercise-induced changes in plasma hormone concentrations involved in the regulation of lipoprotein lipase.
大鼠在自由旋转的工作轮上进行自主运动已被广泛应用，但这种运动训练所导致的肌肉适应性变化却鲜有文献记载。本研究的目的是确定自主运动的大鼠所进行的运动是否会增加比目鱼肌（SM）或股外侧肌红色部分（RV）中的琥珀酸脱氢酶或脂蛋白脂肪酶活性。在自主运动7周或16周后，SM中这两种酶的活性并未增加。在自主运动7周和16周后，RV中的琥珀酸脱氢酶活性适度增加（P<0.05）。RV中的脂蛋白脂肪酶活性大幅增加（P<0.01）。RV中脂蛋白脂肪酶活性的增加与大鼠的跑步距离呈正相关。结果表明，在允许在啮齿动物工作轮上自主运动的大鼠中，仅出现了与肌肉相关的线粒体酶的小幅增加。自主运动训练在含有高比例快肌红纤维的肌肉中诱导了脂蛋白脂肪酶活性的选择性增加，而在以慢肌红纤维为主的肌肉中则没有这种反应。这种差异反应不太可能由运动引起的参与脂蛋白脂肪酶调节的血浆激素浓度变化来解释。
